Analysis of paracellular sodium ion transport in the thin ascending limb of Henle's loop

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We analyzed paracellular sodium ion transport mechanism in the thin ascending limb, which plays an important role in mammalian urine-concentrating mechanism, using in vitro microperfusion technique. We examined whether aldosterone and insulin affected the transepithelial voltages or not. However, the transepithelial voltages remained unchanged. These results meant that both of them did not affect a sodium ion transport in this segment. Besides, according to just a few experiments, insulin like growth factor - 1 also suggested the same result.