Research for novel antimicrobial agents specifically targeting defence system of multi-drug resistant bacteria against oxidative stress.

合适的抗生素在病原微生物引起的传染病的治疗中起着至关重要的作用。目前，抗生素对大多数患者仍然有效。但是，对于一些患者来说，由于抗生素耐药性，他们的疾病已经变得难以治疗，他们迫切需要新的抗生素治疗方案。在本研究中，利用一种专门针对细菌细胞逃避活性氧引起的致命损伤的防御机制的筛选系统，发现一些铁螯合剂作为治疗多重耐药细菌的潜在药物靶点的先导化合物。

An appropriate antibiotic plays a crucial role in treatment of infectious diseases caused by pathogenic microorganisms. At present, antibiotics still work well for most patients. But, for some patients, their diseases have become difficult to treat because of antibiotic resistance, and they urgently need new antibiotic treatment options. In the present research, using a screening system that specifically target a defence mechanism whereby bacterial cells escape from lethal damage caused by reactive oxygene species, some iron chelators were found to be lead compounds as a potential drug target for treatment against multi-drug resistant bacteria.