Research for novel antimicrobial agents specifically targeting defence system of multi-drug resistant bacteria against oxidative stress.

专门针对多重耐药细菌对抗氧化应激的防御系统的新型抗菌药物的研究。

• 批准号: 23591476
• 负责人: SHIBATA Hirofumi
• 金额: $ 3.24万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591476/
• 关键词: 新規抗菌薬; 多剤耐性菌; 感染症; 抗菌活性物質; 鉄捕捉化合物; 耐性菌; 抗菌薬; β‐ラクタム剤; アイルスマー; マンガンイオン; ROS; SOS応答

An appropriate antibiotic plays a crucial role in treatment of infectious diseases caused by pathogenic microorganisms. At present, antibiotics still work well for most patients. But, for some patients, their diseases have become difficult to treat because of antibiotic resistance, and they urgently need new antibiotic treatment options. In the present research, using a screening system that specifically target a defence mechanism whereby bacterial cells escape from lethal damage caused by reactive oxygene species, some iron chelators were found to be lead compounds as a potential drug target for treatment against multi-drug resistant bacteria.

合适的抗生素在治疗由病原微生物引起的感染性疾病中起着至关重要的作用。目前，抗生素对大多数患者仍然有效。但是，对于一些患者来说，由于抗生素耐药性，他们的疾病变得难以治疗，他们迫切需要新的抗生素治疗方案。在本研究中，使用特异性靶向防御机制的筛选系统，从而使细菌细胞逃避由活性氧物质引起的致命损伤，发现一些铁螯合剂是作为治疗多药耐药细菌的潜在药物靶标的先导化合物。

项目成果

Does Mn2+ deprivation turn MRSA into MSSA?

Mn2 剥夺是否会将 MRSA 转变为 MSSA？

• 发表时间: 2012
• 作者: Arai Y;Yamashita K;Mizugishi K;Watanabe T;Kondo T;Kitano T;Kawabata H;Kadowaki N;Takaori-Kondo A.;Hirofumi Shibata
• 通讯作者: Hirofumi Shibata

Does Mn^<2+> Deprivation Turn MRSA into MSSA?

Mn^<2> 剥夺是否会将 MRSA 转变为 MSSA？

• 发表时间: 2013
• 作者: Watanabe T;Yamashita K;Sakurai T;et al;Hirofumi Shibata
• 通讯作者: Hirofumi Shibata

当大学病院における注射薬搬送カートのATP拭き取り調査と細菌調査

我校医院注射药品运输车ATP擦拭调查及细菌调查

• 发表时间: 2012
• 作者: 塚本浩;堀内孝彦;松下 祥;柴田高洋
• 通讯作者: 柴田高洋