Research for novel antimicrobial agents specifically targeting defence system of multi-drug resistant bacteria against oxidative stress.

合适的抗生素在治疗由病原微生物引起的感染性疾病中起着至关重要的作用。目前，抗生素对大多数患者仍然有效。但是，对于一些患者来说，由于抗生素耐药性，他们的疾病变得难以治疗，他们迫切需要新的抗生素治疗方案。在本研究中，使用特异性靶向防御机制的筛选系统，从而使细菌细胞逃避由活性氧物质引起的致命损伤，发现一些铁螯合剂是作为治疗多药耐药细菌的潜在药物靶标的先导化合物。

An appropriate antibiotic plays a crucial role in treatment of infectious diseases caused by pathogenic microorganisms. At present, antibiotics still work well for most patients. But, for some patients, their diseases have become difficult to treat because of antibiotic resistance, and they urgently need new antibiotic treatment options. In the present research, using a screening system that specifically target a defence mechanism whereby bacterial cells escape from lethal damage caused by reactive oxygene species, some iron chelators were found to be lead compounds as a potential drug target for treatment against multi-drug resistant bacteria.