Study on immunotherapy of the intractable EB virus infectious disease using the humanized animal model

在我们实验室登记的有或没有噬血细胞淋巴组织细胞增多症（HLH）的日本Chediak-Higashi综合征儿童中。我们分析了ctl的细胞毒性和脱颗粒活性。在Chediak-Higashi综合征合并噬血细胞淋巴组织细胞增多症的患者中，HLH阳性患者ctl介导的细胞毒性较低或不足，脱颗粒活性也较低。Chediak-Higashi综合征患者有噬血细胞淋巴组织细胞增多症，可根据ctl介导的细胞毒性、脱颗粒活性和遗传分析进行诊断和分类。基于ctl功能分析得到的数据。

Among the Japanese children with Chediak-Higashi syndrome who have or dont have hemophagocytic lymphohistiocytosis (HLH) registered at our laboratory. We analyzed the cytotoxicity and degranulation activity of CTLs. In Chediak-Higashi syndrome who have hemophagocytic lymphohistiocytosis In HLH positive patient with CTL-mediated cytotoxicity was low or deficient, and degranulation activity was also low .Chediak-Higashi syndrome who have hemophagocytic lymphohistiocytosis can be diagnosed and classified on the basis of CTL-mediated cytotoxicity, degranulation activity, and genetic analysis. Based on the data obtained from functional analysis of CTLs.