Composition of fatty acids in phospholipids and functions of neutrophils in patients with malnutrition induced by liver dysfunction after surgery

肝功能障碍术后营养不良患者磷脂脂肪酸组成及中性粒细胞功能

• 批准号: 23591905
• 负责人: TAKIFUJI KATSUNARI
• 金额: $ 2万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591905/
• 关键词: 膜リン脂質脂肪酸構成; 好中球機能; 肝機能障害; 肝硬変

The fatty acid composition of phospholipids in human neutrophils and functions of neutrophils was determined in surgical patients with malnutrition induced by liver dysfunction. The recovery of arachidonic acid(AA) in these neutrophil phospholipids with malnutrition was poorer than that of patients without malnutrition, even if these postoperative courses were safe. As neutrophil functions, the phagocytic activity increased gradually from the first day after an operation to the fourth day and tended to return to a preoperative value on the 14th day. On the seventh day, the decrease in the phagocytic activity was correlated with the decrease rate of AA in neutrophil phospholipids of patients with malnutrition induced by liver dysfunction.These findings show that the malnutrition induced by liver dysfunction may affect the amount of arachidonic acid in the neutrophil phospholipids and the phagocytic activity of the neutrophil after surgery.

本文测定了肝功能不全引起的营养不良外科病人中性粒细胞磷脂脂肪酸组成和中性粒细胞功能。营养不良患者的中性粒细胞磷脂中花生四烯酸（AA）的恢复比无营养不良患者差，即使这些术后疗程是安全的。 随着中性粒细胞功能的恢复，术后第1天至第4天吞噬活性逐渐增强，第14天趋于恢复至术前水平。 术后第7天，肝功能异常引起的营养不良患者中性粒细胞吞噬功能的下降与中性粒细胞磷脂中花生四烯酸的下降率相关，提示肝功能异常引起的营养不良可能影响中性粒细胞磷脂中花生四烯酸的含量，影响术后中性粒细胞的吞噬功能。