Establishment and application of cancer-tissue originated spheroids(CTOSs) of gynecologic cancer

妇科癌症患者事先检查药敏试验可能是有价值的。本研究的目的是建立一种使用CTOS(癌症组织起源的球体)的药物敏感性检测方法，该方法培养通过手术提取的癌细胞。结果表明，在子宫内膜癌中，从浆液性腺癌中制备并维持CTOS的成功率很高。此外，在抑制信号相关肿瘤生长的药物中，mTOR抑制剂、核因子-kB抑制剂显示出中等活性。

Drug sensitivity test for the patient of gynecology cancer by checking beforehand may give a merit. The aim of this study is establishment of a drug sensitivity examination using CTOS (cancer tissue-originated spheroid) which cultured the cancer cell extracted by an operation. As a result, it was revealed that among endometrial cancer, CTOS derived from the serous adenocarcinoma was prepared and maintained with high success rate. In addition, among the drugs which inhibit a signal related cancer growth, mTOR inhibitor, NF-kB inhibitor showed moderate activity.