Basic study of novel endodontic cement

矿物三氧化物骨料（MTA）已被广泛用作牙髓胶合剂。但MTA也有缺点：处理性能不佳，凝结时间较长。本研究的目的是开发新的牙髓粘固剂。磷酸钙胶结剂（CPCs）具有较好的处理性能和较短的固化时间；预混CPC和氟磷灰石形成CPC。与MTA相比，我们评估了成骨细胞的矿化能力和CPCs的大鼠皮下组织反应。这些CPCs显示出与MTA相同的细胞增殖、碱性磷酸酶活性、矿化结节形成和结节内钙含量。这些结果表明，这些CPCs有可能成为一种新型的根管粘接剂。

Mineral Trioxide Aggregate (MTA) has been in widespread use as endodontic cements. However, MTA has disadvantages: it does not have good handling property, and the setting time is relatively long. The aim of this study is to develope new endodontic cements.Calcium phosphate cements (CPCs) has been improved for good handling property and short setting time; Premixed CPC and Fluorapatite forming CPC. Mineralizing ability in osteoblasts and rat subcutaneous tissue response of CPCs were evaluated when compared to MTA. These CPCs indicated the same cell proliferation, alkaline phosphatase activity, mineralized nodule formation, and calcium contents in nodules as those of MTA. Theese results suggest that these CPCs has the possibility of novel endodontic cement.