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Optically regulating the synaptic plasticity at the level of single synaptic spine.

Optically regulating the synaptic plasticity at the level of single synaptic spine.
在单个突触棘水平上光学调节突触可塑性。
批准号：
23650197
负责人：
NAKAMURA Hideki
金额：
$2.41万
依托单位：
Waseda University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650197/
关键词：
神経可塑性ケミカルバイオロジー神経細胞生物学

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中文摘要
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英文摘要
As a preliminary step toward the establishment of technical methods to manipulate the synaptic transmission by rapamycin-induced protein dimerization paradigm, two plasmid libraries were constructed; PSD-95-based construct library and Rho GTPase family-based library. These libraries will contribute to the development of rapamycin-based methods to study synaptic plasticity in neuronal cells. To evaluate the rapamycin-induced protein dimerization within neurons, methods to monitor the diffusion kinetics of soluble proteins in the cell type were also established.
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会议论文
Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier.
DOI： 10.1038/nchembio.1252
发表时间： 2013-07
期刊： NATURE CHEMICAL BIOLOGY
影响因子： 14.8
作者： [Lin, Yu-Chun, Niewiadomski, Pawel, Lin, Benjamin, Nakamura, Hideki, Phua, Siew Cheng, Jiao, John, Levchenko, Andre, Inoue, Takafumi, Rohatgi, Rajat, Inoue, Takanari]
通讯作者： Inoue, Takanari
Proteomic analysis of multiple primary cilia reveals a novel mode of ciliary development in mammals.
DOI： 10.1242/bio.20121081
发表时间： 2012-08-15
期刊： Biology open
影响因子： 2.4
作者： [Narita K, Kozuka-Hata H, Nonami Y, Ao-Kondo H, Suzuki T, Nakamura H, Yamakawa K, Oyama M, Inoue T, Takeda S]
通讯作者： Takeda S
Direct involvement of HTLV-1 for pathogenesis of Sjogren's syndrome
Multidirectional investigation to elucidate an effector site of HTLV-1 and molecular machinery in Sjogren's syndrome
  • 批准号：
    16K09899
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.0万
  • 财政年份：
    2016
  • 负责人：
    NAKAMURA Hideki
  • 依托单位：
    Nagasaki University
Elucidation of mechanism for HTLV-I-associated Sjogren's syndrome
  • 批准号：
    25461477
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.16万
  • 财政年份：
    2013
  • 负责人：
    NAKAMURA Hideki
  • 依托单位：
    Nagasaki University
Safety assessment of signalized intersections through modeling pedestrian-vehicle conflicts
  • 批准号：
    22360205
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $8.57万
  • 财政年份：
    2010
  • 负责人：
    NAKAMURA Hideki
  • 依托单位：
    Nagoya University
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