Effects of intravenous anesthetics on the angiotensin II receptor of vascular smooth muscle cells

在接受血管紧张素II 1型受体拮抗剂或血管紧张素转换酶抑制剂的患者中，即使降压效果相同，血压也比接受钙拮抗剂的患者低。我研究了各种静脉麻醉药是否参与了血管紧张素II 1型受体的表达水平。结果表明，静脉麻醉药对血管紧张素Ⅱ1型和2型受体均无明显影响。我认为今后有必要进一步研究静脉麻醉药对肾素-血管紧张素系统的影响。

In patients receiving angiotensin II type 1 receptor antagonist or angiotensin converting enzyme inhibitor, blood pressure is lowered than patients receiving calcium antagonist even if the anti-hypertensive effect is the same extent.I examined whether various intravenous anesthetics is involved in the expression level of the angiotensin II type 1 receptor. It was found that intravenous anesthetics was not affect the type 1 nor type 2 angiotensin II receptors. I considered that it is necessary to further study in the future about the effects of intravenous anesthetics on the renin-angiotensin system.