Effects of intravenous anesthetics on the angiotensin II receptor of vascular smooth muscle cells

静脉麻醉药对血管平滑肌细胞血管紧张素II受体的影响

• 批准号: 23791711
• 负责人: MIYAZAKI Ryohei
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791711/
• 关键词: 静脈麻酔薬; アンジオテンシンII; レニンアンジオテンシン系

In patients receiving angiotensin II type 1 receptor antagonist or angiotensin converting enzyme inhibitor, blood pressure is lowered than patients receiving calcium antagonist even if the anti-hypertensive effect is the same extent.I examined whether various intravenous anesthetics is involved in the expression level of the angiotensin II type 1 receptor. It was found that intravenous anesthetics was not affect the type 1 nor type 2 angiotensin II receptors. I considered that it is necessary to further study in the future about the effects of intravenous anesthetics on the renin-angiotensin system.

在接受血管紧张素II 1型受体拮抗剂或血管紧张素转换酶抑制剂治疗的患者中，即使降压效果相同，血压也比接受钙拮抗剂治疗的患者低。我研究了各种静脉麻醉药是否涉及血管紧张素II 1型受体的表达水平。结果表明，静脉麻醉药对血管紧张素Ⅱ 1型和2型受体无明显影响。认为今后有必要进一步研究静脉麻醉药对肾素-血管紧张素系统的影响。