Development of Novel Carbon-Carbon Bond Forming Reactions for Application to Industrial Process

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I have succeeded in highly enantioselective and atom-economical reactions, especially [2 + 2] cycloaddition of diverse array of alkynes with trifluoropyruvate using chiral dicationic BINAP-Pd catalyst to provide the unprecedentedly stable oxetene derivatives. The reaction takes place with good-to-excellent yields and various substituents on the internal alkynes. This catalytic process offers not only the first synthetic method of stable oxetene derivatives but also new entry to oxetenes as a novel chiral trifluoromethyl building block for pharmaceuticals and agrochemicals.