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Characterization and application of hydrophobic functionalities bearing heavier group 14 atoms

Characterization and application of hydrophobic functionalities bearing heavier group 14 atoms
带有较重14族原子的疏水官能团的表征和应用
批准号:
23790128
负责人:
FUJII Shinya
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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英文摘要
Systematic synthesis and characterization of simple phenols bearing a trialkyl(aryl)silyl or trialkyl(aryl)germyl functional group as a hydrophobic substituent were investigated. These silicon and germanium analogs exhibited higher hydrophobicity than the corresponding carbon analogs, with a difference in logP value of approximately 0.6, independent of the alkyl(aryl) species. The trialkylsilyl- and trialkylgermylphenols exhibited more potent estrogenic activity as compared with the carbon analogs. The substituent parameters and structure-activity relationship may be helpful for drug discovery utilizing the heavier group 14 elements.
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Design and synthesis of novel carborane-containing AR antagonists having a grycerol moiety based on the co-crystal structure of bicalutamide with hAR LBD.
基于比卡鲁胺与 hAR LBD 的共晶结构,设计和合成具有甘油部分的新型含碳硼烷 AR 拮抗剂。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kaise, A., Goto, T., Fujii, S., Ohta, K., Endo, Y.]
通讯作者: Y.
ビタミンK酸化誘導体の系統的合成とその生理活性
维生素K氧化衍生物的系统合成及其生理活性
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Ikuhiko Nakase, Shinya Okumura, Sayaka Katayama, Hisaaki Hirose, Silvia Pujals, Hirofumi Yamaguchi, Satoko Arakawa, Shigeomi Shimizu, Shiroh Futaki, 清水章貴]
通讯作者: 清水章貴
Development and structural basis of novel non-secosteroidal VDR ligands based on hydrophobic carborane cage
基于疏水碳硼烷笼的新型非甾体VDR配体的开发和结构基础
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Fujii, S.; Masuno, H.; Nakabayashi, M.; Hirano, T.; Kawachi, E.; Ito, N.; Kagechika, H.]
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Development of Nuclear Receptor Ligands Based on Carborane as Hydrophobic Core Structure
基于碳硼烷作为疏水核心结构的核受体配体的研制
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Fujii, S.; Yamada, A.; Ohta, K.; Endo, Y.; Kagechika, H.]
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