Molecular basis of Polycomb and Trithorax complexes in the maintenance of immunological memory

因免疫系统失调而引起的过敏性疾病，据说是日本的国病。我们关注Th2细胞，因为它们被认为在过敏性疾病的发展中起主导作用。Polycomb和Trithorax蛋白通过与特定基因的结合来调节Th2细胞的功能。我们用一种叫做ChIP-seq的先进技术绘制了它们结合的地方的基因图谱，发现了一些意想不到的特征。此外，我们发现缺乏Trithorax分子的小鼠的过敏反应减弱。我们希望这些发现将应用于过敏性疾病治疗的发展。

Allergic disease, which is caused by a disorder of the balance of the immune system, is said to be the Japanese national disease. We focus on Th2 cells because they are thought to play leading role in development of the allergic disease. Polycomb and Trithorax proteins regulate Th2 cell function via binding to specific genes. We made gene maps of the place where they bound using an advanced technique called the ChIP-seq method and discovered some unexpected characteristics. In addition, we found that allergic reactions were attenuated in the mice lacking the Trithorax molecules. We hope that these findings will be applied to the development of therapies for allergic disease.