The development of novel colorectal cancer screening method using exosomal antisense RNA in serum

外切体是从各种细胞释放到细胞外空间的微囊。据报道，外体内的成分因分泌细胞类型的不同而不同。在本研究中，我们在三个结直肠癌(CRC)细胞系分泌的外切体中鉴定了一种mRNAs、microRNAs和天然反义RNAs。在本研究中，我们首次发现它们的天然反义RNA存在于外切体中。目前，对血清中结直肠癌特异性天然反义RNA的搜索已经完成。

Exosomes are microvesicles that are released from various cells into the extracellular space. It has been reported that the components within exosomes vary according to the type of secreted cell. In the present study, we identified a species of mRNAs, microRNAs, and natural antisense RNAs within the exosomes secreted from the three colorectal cancer (CRC) cell lines. We discovered that their natural antisense RNAs were within exosomes for the first time in the present study. Currently, the searching of exosomal CRC-specific natural antisense RNAs in serum has been performed.