Liver toxicity caused by nanoparticle-rich or filtered diesel exhaust

柴油机尾气是一种主要的空气污染物，其中含有许多纳米颗粒。有关富含纳米颗粒的柴油尾气(NR-DE)对肝脏影响的研究很少。在本研究中，基因芯片分析表明，约140nRg/m~3的NR-DE暴露1个月可引起大鼠脂类平衡的破坏。此外，暴露于NR-DE和过滤的NR-DE，即不含纳米颗粒的NR-DE，会增加小鼠的肝脏脂肪酸。这些结果表明，柴油机尾气中的气体成分对人体的脂质代谢有一定的影响，其主要影响因素是内燃机尾气。

Diesel exhaust is a main airborne contaminant and includes many nanoparticles. Little studies reporting effects of nanoparticle-rich diesel exhaust (NR-DE) on liver have been conducted. In the present study, DNA microarray analysis showed that about 140 μg/m^3NR-DE for 1 month exposure caused the disruption of lipid homeostasis in rats. Additionally, exposure of NR-DE and filtered NR-DE, i.e. NR-DE without nanoparticles, increased hepatic fatty acids in mice. These results suggest that diesel exhaust induces the disturbance of lipid homeostasis and the main player exist in gas component in diesel exhaust.