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Role of cellular senescence factor Ecrg4-investigating its expression and identifying its receptor which may be a therapeutic target in Alzheimer's Disease

Role of cellular senescence factor Ecrg4-investigating its expression and identifying its receptor which may be a therapeutic target in Alzheimer's Disease
细胞衰老因子 Ecrg4 的作用——研究其表达并鉴定其受体,这可能是阿尔茨海默病的治疗靶点
批准号:
23791001
负责人:
KUJURO Yuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
在ApoE 4阿尔茨海默病转基因小鼠的脑中,与非转基因小鼠相比,SA-β-gal活性和Ecrg 4表达升高。我们的数据表明,细胞衰老可能是阿尔茨海默病的致病机制之一。通过
英文摘要
In the brains of ApoE4 Alzheimer’s Disease transgenic mice, SA-β-gal activity and expression of Ecrg4 was elevated compared to non transgenic mice. Our data suggests that cellular senescence might be one of the causal mechanisms of Alzheimer’s Disease. By
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会议论文
New role of Parkin as a E3 in the causal mechanism of Parkinson's disease
  • 批准号:
    25860721
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.58万
  • 财政年份:
    2013
  • 负责人:
    KUJURO Yuki
  • 依托单位:
海外基金