Evaluation of a screening method based on the"T-cell dysfunction" hypothesis of major depressive disorder.

基于重度抑郁症“T细胞功能障碍”假说的筛查方法的评估。

• 批准号: 23659561
• 负责人: SUZUKI Katsuaki
• 金额: $ 2.33万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659561/
• 关键词: 精神薬理学; うつ病; バイオマーカー; ApoER2; mRNA; リポ蛋白受容体; 早期診断

We measured the mRNA levels of apolipoprotein E receptor type 2 (ApoER2) and very low-density lipoprotein receptor (VLDLR) in peripheral blood lymphocytes from 43 patients with major depressive disorder (27 drug-free patients and 16 medicated patients) and 43 age-matched healthy controls using a quantitative real-time RT-PCR method. The correlations between mRNA levels of both receptors and clinical variables in patients were also examined. The expression of ApoER2 mRNA, but not VLDLR, was significantly lower in patients as compared to controls, irrespective of the medication status. There was nostatistically significant correlation between the reduction of ApoER2 mRNA levels and any of the clinical variables measured in patients. Results from this preliminary study suggest that the expression of ApoER2 may serve as a traitmarker for major depressive disorder.

采用实时定量RT-PCR方法检测了43例抑郁症患者(非药物组27例，药物组16例)和43例年龄匹配的健康对照组外周血淋巴细胞载脂蛋白E受体2(ApoER2)和极低密度脂蛋白受体(VLDLR)的mRNA水平。两种受体的信使核糖核酸水平与患者临床变量的相关性也被检验。与对照组相比，患者组ApoER2mRNA的表达显著降低，但VLDLR的表达不显著，与用药状态无关。ApoER2 mRNA水平的降低与患者所测量的任何临床变量之间没有统计学意义的相关性。这项初步研究的结果表明，ApoER2的表达可能是严重抑郁障碍的一个指标。

项目成果

HBC Study Team. Psychosocial determinants of mistimed and unwanted pr gnancy: the Hamamatsu Birth Cohort (HBC) study

HBC 研究团队。

• 发表时间: 2012
• 期刊: Matern Child Health J
• 作者: Takahashi S;Tsuchiya KJ;Matsumoto K;Suzuki K;Mori N;Takei N
• 通讯作者: Takei N

Altering the expression balance of hnRNP C1 and C2 changes the expression of myelination-related genes

• DOI: 10.1016/j.psychres.2011.05.043
• 发表时间: 2011-12-30
• 期刊: PSYCHIATRY RESEARCH
• 影响因子: 11.3
• 作者: Iwata, Keiko;Matsuzaki, Hideo;Mori, Norio
• 通讯作者: Mori, Norio

レスモデルにおける局所脳血流・脳糖代謝解析

反应模型中局部脑血流及脑糖代谢分析

• 发表时间: 2012
• 作者: 亀野 陽亮;松崎 秀夫;高橋 健二;岩田 圭子
• 通讯作者: 岩田 圭子

Psychosocial determinants of mistimed and unwanted pregnancy: the Hamamatsu Birth Cohort (HBC) Study

不合时宜和意外怀孕的心理社会决定因素：滨松出生队列 (HBC) 研究

• DOI: 10.1007/s10995-011-0881-y
• 发表时间: 2012
• 期刊: Maternal & Child Health Journal
• 影响因子: 2.3
• 作者: 1.Iwata K;Matsuzaki H;Tachibana T;Ohno K;Yoshimura S;Takamura H;Yamada K;Matsuzaki S;Nakamura K;Tsuchiya KJ;Matsumoto K;Tsujii M;Sugiyama T;Katayama T;Mori N;Takahashi
• 通讯作者: Takahashi

Vldlr overexpression causes hyperactivity in rats.

• DOI: 10.1186/2040-2392-3-11
• 发表时间: 2012-10-30
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Iwata K;Izumo N;Matsuzaki H;Manabe T;Ishibashi Y;Ichitani Y;Yamada K;Thanseem I;Anitha A;Vasu MM;Shimmura C;Wakuda T;Kameno Y;Takahashi T;Iwata Y;Suzuki K;Nakamura K;Mori N
• 通讯作者: Mori N