Evaluation of proshodontic treatment on diabetes prevention using incretin as a indicator.

以肠促胰岛素为指标评价口腔修复治疗对预防糖尿病的作用。

• 批准号: 23659906
• 负责人: HOSOKAWA Ryuji
• 金额: $ 2.41万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659906/
• 关键词: インクレチン; 咀嚼機能的評価; 血糖値コントロール; 糖尿病; 補綴治療介入; インスリン; 咀嚼障害; GLP-1; 義歯; インプラント

Glucagon-like peptide 1(GLP-1) is secreted from the small intestine to the blood in response to glucose intake during a meal, and it stimulates pancreatic insulin secretion. To investigate the relationship between chewing and postprandial blood glucose related to incretin secretion, we compared the levels following usual eating with the changes of blood glucose, serum insulin, and plasma active GLP-1 concentrations after young healthy volunteers ate a test meal in one of three specified ways : 1.unilateral chewing, 2.quick eating, 3.30 times chewing per one bite. Ten volunteers participated in each group. There were no differences in the blood glucose or insulin concentrations between usual eating and the three specified ways of eating. Plasma active GLP-1 concentration did not change by unilateral chewing or quick eating, but it increased significantly by 30 times chewing per one bite compared with usual eating at 30 minutes after a meal.

胰高血糖素样肽 1 (GLP-1) 响应进餐期间摄入的葡萄糖，从小肠分泌到血液中，并刺激胰腺胰岛素分泌。为了研究咀嚼与肠促胰素分泌相关的餐后血糖之间的关系，我们比较了年轻健康志愿者以三种指定方式之一进食测试餐后的正常饮食水平与血糖、血清胰岛素和血浆活性GLP-1浓度的变化：1.单侧咀嚼，2.快速进食，每口咀嚼3.30次。每组有十名志愿者参加。正常饮食和三种特定饮食方式之间的血糖或胰岛素浓度没有差异。单侧咀嚼或快速进食时，血浆活性GLP-1浓度没有变化，但在餐后30分钟时，每咬一口咀嚼30次，与平时进食相比，血浆活性GLP-1浓度显着增加。