Evaluation of proshodontic treatment on diabetes prevention using incretin as a indicator.

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Glucagon-like peptide 1(GLP-1) is secreted from the small intestine to the blood in response to glucose intake during a meal, and it stimulates pancreatic insulin secretion. To investigate the relationship between chewing and postprandial blood glucose related to incretin secretion, we compared the levels following usual eating with the changes of blood glucose, serum insulin, and plasma active GLP-1 concentrations after young healthy volunteers ate a test meal in one of three specified ways : 1.unilateral chewing, 2.quick eating, 3.30 times chewing per one bite. Ten volunteers participated in each group. There were no differences in the blood glucose or insulin concentrations between usual eating and the three specified ways of eating. Plasma active GLP-1 concentration did not change by unilateral chewing or quick eating, but it increased significantly by 30 times chewing per one bite compared with usual eating at 30 minutes after a meal.