Establishment of predictive equation for the prognosis of oral squamous cell carcinoma patients on the basis of the expression of ING gene family

基于ING基因家族表达的口腔鳞癌患者预后预测方程的建立

• 批准号: 23659958
• 负责人: TAKANO Yasuo
• 金额: $ 2.25万
• 依托单位: Kanagawa Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659958/
• 关键词: 脱アセチル化酵素; SIRT1; 癌抑制遺伝子; 頭頸部扁平上皮癌; エピジェネティクス; 頭頸部癌; SIRT1発現

We examined SIRT1, a binding protein to ING1b and Class III HDAC (histone deacetylase), expression of head and neck squamous cell carcinoma patients to investigate the bio-marker for prediction of their prognosis by the immunohistochemical study. The results were, 1) The SIRT1 expression related to higher age, 2) higher in oral cancer patients, 3) lower in lymph nodes' metastasis cases, 4) lower in advanced cases in patho-clinical stages. Thus, the SIRT1 expression inversely correlated in proportion to cancer progression. SIRT1 expression was good indicator for good prognosis of HNSCC patients, especially in oral cancer patients. And also it was independent good prognostic factor in multivariate analyses.

我们通过免疫组化方法检测了头颈部鳞状细胞癌组织中ING 1b结合蛋白SIRT 1和III类组蛋白去乙酰化酶（Class III HDAC）的表达，探讨其作为预测头颈部鳞状细胞癌患者预后的生物标志物。结果表明：1）SIRT 1的表达与年龄有关; 2）口腔癌患者SIRT 1的表达高于正常口腔黏膜;因此，SIRT 1表达与癌症进展成比例负相关。SIRT 1表达是HNSCC患者预后良好的良好指标，特别是在口腔癌患者中。在多因素分析中，它也是独立的好预后因素。

项目成果

RAS gene mutation in follicular thyroid tumors : frequency and the clinical significance

滤泡性甲状腺肿瘤中RAS基因突变的频率及其临床意义

• 发表时间: 2012
• 作者: Miyagi Y;Yoshida A;Matsukuma S;Sakuma S;Koizume S;Yoshihara M;Okamoto N;Yokose T;Kondo T;Takano Y
• 通讯作者: Takano Y

High expression is associated with poorer survival in patients with gastric cancer

高表达与胃癌患者较差的生存率相关

• 发表时间: 2012
• 作者: Noguchi A;Kikuchi K;Takano Y
• 通讯作者: Takano Y

Inhibitor of hepatocellular carcinoma cell adhesion by ectopic synthesis of TFPl1

TFPl1异位合成抑制肝癌细胞粘附

• 发表时间: 2012
• 作者: Ito S;Koizume S;Takano Y;Miyagi Y
• 通讯作者: Miyagi Y

Survaival of ovarian cancer cells mediated by ICMA1 expression induced by HIF1/Sp1/mTOR interplay under ischemic condition

HIF1/Sp1/mTOR相互作用诱导ICMA1表达介导的卵巢癌细胞在缺血条件下的存活

• 发表时间: 2012
• 作者: Koizume S;Miyagi E;Hirahara F;Yoshihara M;Takano Y;Miyagi Y
• 通讯作者: Miyagi Y

Subnuclar localization and degradation of ING4 is correlated with tumotigenesis and progression of HNSCC

ING4 的核下定位和降解与 HNSCC 的肿瘤发生和进展相关

• 发表时间: 2011
• 作者: Noguchi A;Takano Y;Kikuchi K
• 通讯作者: Kikuchi K