Functional roles of IQ-ArfGEF at excitatory postsynaptic sites
Functional roles of IQ-ArfGEF at excitatory postsynaptic sites
批准号:
23700416
负责人:
FUKAYA Masahiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
In this study, I focused on IQ-ArfGEF, one of the excitatory postsynaptic molecules, which causes nonsyndromic mental retardation. To reveal the functional mechanisms of IQ-ArfGEF at postsynaptic sites, IQ-ArfGEF knockout mice were generated. Using IQ-ArfGEF knockout mice, many neuronal and glial marker molecules were screened by immunoblot and immunohistochemical assays. Consequently, impairment of IQ-ArfGEF was accompanied by upregulation of some neural molecules in the brain.
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DOI:
10.1038/nn.3357
发表时间:
2013-05
期刊:
NATURE NEUROSCIENCE
影响因子:
25
作者:
[Kang, Shin H., Li, Ying, Fukaya, Masahiro, Lorenzini, Ileana, Cleveland, Don W., Ostrow, Lyle W., Rothstein, Jeffrey D., Bergles, Dwight E.]
通讯作者:
Bergles, Dwight E.
成体マウス脳におけるARF6活性化因子BRAG2/IQSEC1 の細胞内局在解析
成年小鼠脑中 ARF6 激活剂 BRAG2/IQSEC1 的亚细胞定位分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[深谷昌弘, 原芳伸, 阪上洋行]
通讯作者:
阪上洋行
Postsynaptic and endosomal localization of BRAG2/GEP100 in the adult mouse brain
成年小鼠大脑中 BRAG2/GEP100 的突触后和内体定位
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[深谷昌弘, 原芳伸, 阪上洋行]
通讯作者:
阪上洋行
DOI:
10.1083/jcb.201110034
发表时间:
2012-05-14
期刊:
The Journal of cell biology
影响因子:
--
作者:
[Kageyama Y, Zhang Z, Roda R, Fukaya M, Wakabayashi J, Wakabayashi N, Kensler TW, Reddy PH, Iijima M, Sesaki H]
通讯作者:
Sesaki H
Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina
小鼠视网膜中布雷菲德菌素 A 抗性鸟嘌呤核苷酸交换因子 BRAG2 和 BRAG3 的独特突触定位模式
DOI:
10.1002/cne.23206
发表时间:
2013
期刊:
J. Comp. Neurol
影响因子:
--
作者:
[Sakagami H, Katsumata O, Hara Y, Tamaki H, Watanabe M, Harvey RJ, Fukaya M]
通讯作者:
Fukaya M
共 8 条
Molecular anatomical studies on the localization and functions of NMDA receptors in inhibitory neurons
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批准号:19700315
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.36万
-
财政年份:2007
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负责人:FUKAYA Masahiro
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依托单位:
海外基金