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Functional roles of IQ-ArfGEF at excitatory postsynaptic sites

Functional roles of IQ-ArfGEF at excitatory postsynaptic sites
IQ-ArfGEF 在兴奋性突触后位点的功能作用
批准号:
23700416
负责人:
FUKAYA Masahiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
In this study, I focused on IQ-ArfGEF, one of the excitatory postsynaptic molecules, which causes nonsyndromic mental retardation. To reveal the functional mechanisms of IQ-ArfGEF at postsynaptic sites, IQ-ArfGEF knockout mice were generated. Using IQ-ArfGEF knockout mice, many neuronal and glial marker molecules were screened by immunoblot and immunohistochemical assays. Consequently, impairment of IQ-ArfGEF was accompanied by upregulation of some neural molecules in the brain.
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DOI: 10.1038/nn.3357
发表时间: 2013-05
期刊: NATURE NEUROSCIENCE
影响因子: 25
作者: [Kang, Shin H., Li, Ying, Fukaya, Masahiro, Lorenzini, Ileana, Cleveland, Don W., Ostrow, Lyle W., Rothstein, Jeffrey D., Bergles, Dwight E.]
通讯作者: Bergles, Dwight E.
成体マウス脳におけるARF6活性化因子BRAG2/IQSEC1 の細胞内局在解析
成年小鼠脑中 ARF6 激活剂 BRAG2/IQSEC1 的亚细胞定位分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [深谷昌弘, 原芳伸, 阪上洋行]
通讯作者: 阪上洋行
Postsynaptic and endosomal localization of BRAG2/GEP100 in the adult mouse brain
成年小鼠大脑中 BRAG2/GEP100 的突触后和内体定位
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [深谷昌弘, 原芳伸, 阪上洋行]
通讯作者: 阪上洋行
DOI: 10.1083/jcb.201110034
发表时间: 2012-05-14
期刊: The Journal of cell biology
影响因子: --
作者: [Kageyama Y, Zhang Z, Roda R, Fukaya M, Wakabayashi J, Wakabayashi N, Kensler TW, Reddy PH, Iijima M, Sesaki H]
通讯作者: Sesaki H
8
    Molecular anatomical studies on the localization and functions of NMDA receptors in inhibitory neurons
    • 批准号:
      19700315
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.36万
    • 财政年份:
      2007
    • 负责人:
      FUKAYA Masahiro
    • 依托单位:
    海外基金