Elucidation of insecticide detoxification by hydrolases and evaluation of species difference between humans and experimental animals
Elucidation of insecticide detoxification by hydrolases and evaluation of species difference between humans and experimental animals
批准号:
23710042
负责人:
NISHI Kosuke
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
利用杆状病毒表达系统构建了人肝脏表达的重组水解酶文库。当用拟除虫菊酯及其含有荧光素的衍生物对文库进行筛选时,发现了能降解杀虫剂的新型酶。对酶的生化特性进行了分析。
英文摘要
A library of recombinant hydrolases expressed in human liver was generated using the baculovirus expression system. When the library was screened with pyrethroids and their derivatives containing a fluorochrome, novel enzymes that hydrolyze the insecticides were discovered. Biochemical characteristics of the enzymes was analyzed.
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Studies on immunotoxicity of o-phenylphenol (OPP) and metabolite
邻苯基苯酚(OPP)及其代谢物的免疫毒性研究
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sugahara T, Nakata Y, Nishi K, Nishimoto S]
通讯作者:
Nishimoto S
DOI:
10.1271/bbb.100490
发表时间:
2011-01-01
期刊:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
影响因子:
1.6
作者:
[Nishi, Kosuke, Kondo, Ai, Sugahara, Takuya]
通讯作者:
Sugahara, Takuya
DOI:
10.1021/jf203585b
发表时间:
2012-02-22
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
影响因子:
6.1
作者:
[Inui, Hideyuki, Takeuchi, Tetsuya, Ohkawa, Hideo]
通讯作者:
Ohkawa, Hideo
DOI:
10.1016/j.bmcl.2012.07.074
发表时间:
2012-09-15
期刊:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
影响因子:
2.7
作者:
[Kim, In-Hae, Nishi, Kosuke, Kasagami, Takeo, Morisseau, Christophe, Liu, Jun-Yan, Tsai, Hsing-Ju, Hammock, Bruce D.]
通讯作者:
Hammock, Bruce D.
Immunomodulatory effects of citrus fruit auraptene in vitro and in vivo
柑橘类水果 auraptene 的体外和体内免疫调节作用
DOI:
10.1016/j.jff.2012.06.005
发表时间:
2012
期刊:
Journal of Functional Foods
影响因子:
5.6
作者:
[Daifuku M, Nishi K, Okamoto T, Nakano H, Nishimoto S, Sugahara T, Kota Kanda et al., Agus Budiawan Naro Putra et al., Kosuke Nishi et al., In-Hae Kim et al., Sogo Nishimoto et al.]
通讯作者:
Sogo Nishimoto et al.
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