Molecular bases and their regulations of mRNA aberrations in neuromuscular transmission defects and other muscular diseases

神经肌肉传递缺陷和其他肌肉疾病中mRNA畸变的分子基础及其调控

• 批准号: 24390221
• 负责人: OHNO Kinji
• 金额: $ 11.48万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390221/
• 关键词: 先天性筋無力症候群; 神経筋接合部; RSPO2; LGR5; LRP4; Wnt; ColQ

项目成果

Global analysis of RNA-binding sites of CUGBP1 and MBNL1 reveal their preferential binding to 3’ UTRs to regulate mRNA stability

对 CUGBP1 和 MBNL1 RNA 结合位点的全局分析揭示了它们优先结合 3 UTR 来调节 mRNA 稳定性

• 发表时间: 2012
• 作者: Masuda A;Andersen HS;Doktor TK;Okamoto T;Ito I;Andresen BS;Ohno K
• 通讯作者: Ohno K

Molecular hydrogen alters signaling pathways and gene expression profiles in multiple mouse organs

氢分子改变多个小鼠器官的信号通路和基因表达谱

• 发表时间: 2012
• 作者: Sobue S;Yamai K;Ito M;Ohno K;Ito M;Ohkuwa T;Ichihara M
• 通讯作者: Ichihara M

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.

• DOI: 10.1186/1471-2164-14-248
• 发表时间: 2013-04-15
• 期刊: BMC genomics
• 影响因子: 4.4
• 作者: Tanisawa K;Mikami E;Fuku N;Honda Y;Honda S;Ohsawa I;Ito M;Endo S;Ihara K;Ohno K;Kishimoto Y;Ishigami A;Maruyama N;Sawabe M;Iseki H;Okazaki Y;Hasegawa-Ishii S;Takei S;Shimada A;Hosokawa M;Mori M;Higuchi K;Takeda T;Higuchi M;Tanaka M
• 通讯作者: Tanaka M

EMG findings at non-myotonia and myotonia states in patients with Na channelopathies

钠通道病患者非肌强直和肌强直状态的肌电图表现

• 发表时间: 2012
• 作者: Kinoshita M;Kokunai Y;Kubota T;Takahashi M;Sasaki R;Ohno K;Hirose K
• 通讯作者: Hirose K

A comprehensive and efficient algorithm to predict splicing consequences of intronic nucleotide substitutions in the human genome

一种全面有效的算法来预测人类基因组中内含子核苷酸取代的剪接结果

• 发表时间: 2012
• 作者: Shibata A;Masuda A;Ohno K
• 通讯作者: Ohno K