preparation of metal-oxo complex bearing tridentate ligand: development of asymmetric oxidation reaction assisted by additional ligand

点击翻译按钮获取中文摘要

On this study, an asymmetric oxidation catalyst controlled by an additional ligand was designed. Although iron-porphyrins are well-known catalysts for oxidations, application of them to asymmetric oxidation are difficult due to their planar structure.I focused on CAZBOX ligand, which has porphyrin-like structure such as planarity and amide-ligands. After numerous attempts, I found that the iron-cazbox complexes catalyze asymmetric epoxidations of alkenes. Mechanistic analyses by ESR and UV present the cazbox ligands show similar reactivity to porphyrins on the oxidation reactions. Furthermore, studies on substituent effect of the ligand disclose that enantioselection of the product depend on electronic interaction between the cazbox ligand and the corresponding substrate. Through these studies, I have developed the chiral ligand CAZBOX bearing porphyrin-like reactivities.