Investigation of role of MafB for tumor immunity

MafB 对肿瘤免疫作用的研究

• 批准号: 24700963
• 负责人: YAMAUCHI Keiko
• 金额: $ 2.83万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700963/
• 关键词: MafB; 腫瘍免疫; マクロファージ; 転写因子; 遺伝子改変マウス; 癌; 癌転移

Role of macrophage transcription factor MafB for tumor immunity was investigated using mice that specifically express dominant negative (DN) MafB in macrophages. B16-F10 melanoma cells were administered to the mice from tail vein. Survival rate was not significantly different between wild type mice and DN-MafB transgenic mice (TG). The number of macrophages in tumors and those around tumors were not different between two groups. Survival rate of untreated mice were similar in both groups. In addition, 6 months after intraperitoneal urethane treatment, the sizes of lung tumors, such as nodules and hyperplasia lesions, were measured. Both sizes of lung nodules and hyperplastic lesions were not significantly different between TG and wild type mice. This study revealed that transcription factor MafB does not play important roles for tumor immunity in mice.

使用在巨噬细胞中特异性表达显性阴性（DN）MafB的小鼠研究巨噬细胞转录因子MafB对于肿瘤免疫的作用。将B16-F10黑色素瘤细胞从尾静脉给予小鼠。野生型小鼠和DN-MafB转基因小鼠（TG）之间的存活率没有显著差异。两组间瘤内及瘤周巨噬细胞数量无差异。两组未处理小鼠的存活率相似。此外，在腹腔内乌拉坦治疗后6个月，测量肺肿瘤的大小，如结节和增生病变。肺结节和增生性病变的大小在TG和野生型小鼠之间没有显着差异。本研究表明，转录因子MafB在小鼠肿瘤免疫中不起重要作用。

项目成果

MafB Suppresses Acute Inflammatory Responses In Lipopolysaccharide -Stimulated Lung Injury In Mice

MafB 抑制脂多糖刺激的小鼠肺损伤的急性炎症反应

• 发表时间: 2012
• 作者: Aida Y;Yamauchi K;et al
• 通讯作者: et al

呼吸機能低下は一般住民における心房細動の独立した危険因子である

呼吸功能障碍是普通人群房颤的独立危险因素

• 发表时间: 2013
• 作者: 布宮慶子;柴田陽光;他
• 通讯作者: 他

Elevated serum iron is a potent biomarker for spirometric resistant to cigarette smoke among Japanese males : The Takahata Study

血清铁升高是日本男性肺活量抵抗香烟烟雾的有效生物标志物：高畑研究

• 发表时间: 2014
• 作者: 柴田陽光;山内啓子;他
• 通讯作者: 他

Lung-specific CCL1 overexpression decreases alveolar macrophages in murine BAL.

肺特异性 CCL1 过度表达会减少小鼠 BAL 中的肺泡巨噬细胞。

• 发表时间: 2012
• 作者: Tsuji M;Taguchi A;Ohshima M;Kasahara Y;Sato Y;Tsuda H;Otani K;Yamahara K;Ihara M;Harada-Shiba M;Ikeda T;Matsuyama T.;Watanabe H;菊地利明;Haruyo Ujike et al.;Kishi H
• 通讯作者: Kishi H

Relationship between plasma fibrinogen levels and pulmonary function in the japanese population: the Takahata study.

• DOI: 10.7150/ijms.7256
• 发表时间: 2013
• 期刊: International journal of medical sciences
• 影响因子: 3.6
• 作者: Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato M;Sato K;Kimura T;Nemoto T;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
• 通讯作者: Kubota I