Analysis of antisense RNA and development of new diagnostics of gastrointestinal cancer using blood.
Analysis of antisense RNA and development of new diagnostics of gastrointestinal cancer using blood.
批准号:
24701001
负责人:
KOHNO Keisuke
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
The aim of this research is to analyze of antisense RNA and develop of new diagnostics of gastrointestinal cancer using blood.We identified 20 anti-sense RNA that is changing with the healthy people in the blood of patients with colorectal cancer. These antisenseRNA was possible to clearly distinguish the healthy people and colon cancer patients. We also identified 15 miRNA and 17 miRNA, respectively, changing to healthy people in the blood of exosomes in patients with colon cancer and pancreatic cancer patients. These miRNA was possible to distinguish clearly healthy people and patients with colorectal cancer.From these results, we will develop new low cost custom microarray for diagnosis of gastrointestinal cancer.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
血液中センス/アンチセンスRNAを用いた大腸癌の新規診断法の開発
开发利用血液正义/反义RNA诊断结直肠癌的新方法
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高野恵輔, 朴秀吉, 永井健太郎, 千葉 満, 村田聡一郎, 久倉勝治, 稲川 智, 安江博, 大河内信弘]
通讯作者:
大河内信弘
Diffarential expression profiles of sense and antisense transcripts between HCV-associated carcinoma and hepatocellular corresponding non-cancerous liver tissue
HCV相关癌和肝细胞相应非癌性肝组织之间正义和反义转录物的差异表达谱
DOI:
--
发表时间:
2012
期刊:
Int J Oncol
影响因子:
5.2
作者:
[Nagai K, Kohno K, Chiba M, Pak S, Murata S, Fukunaga K, Kobayashi A, Yasue H, Ohkohchi N]
通讯作者:
Ohkohchi N
REGULATION OF TGF-β AND ITS SIGNAL MOLECULE, SMAD FOR ATTENUATION OF PERITONEAL FIBROSIS.
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批准号:12671058
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:KOHNO Keisuke
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依托单位:
海外基金