Study on Maternal Environmental Factors for Cleft Lip and/or Palate by Transplanting Fertilized Ova

受精卵移植引起唇腭裂的母体环境因素研究

• 批准号: 09672080
• 负责人: NATSUME Nagato
• 金额: $ 1.98万
• 依托单位: Aichi-Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672080/
• 关键词: Cleft lip; Cleft palate; CL; P-prone mouse; A; J mouse; C57; BL mouse; plantation of fertilized ova; maternal environmental factor

1. We carried out screening in 1998 on the incidence of CL/P. Based on those results we made clear if it is possible to reduce the risk of CL/P appearance by transplantation of fertilized ova along with basic treatments.2. As we evaluated the following assumptions : How much influence does maternal environment have on CL/P ? If it has much influence, what kind of patients can be protected from CL/P by transplantation of fertilized ova ? Is it possible to prevent CL/P appearance only by basic treatments ?3. We submitted our study to the Journal "PLASTIC AND RECONSTRUCTIVE SURGERY" and how it is in press.Collaborator : Jun Kuno (Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor)

1.我们在1998年对CL/P的发病率进行了筛查，根据这些结果，我们明确了是否有可能通过沿着基础治疗的受精卵移植来降低CL/P的发生风险.我们评估了以下假设：母体环境对CL/P有多大影响？如果影响较大，那么什么样的患者可以通过受精卵移植避免CL/P？仅通过基础治疗是否可能预防CL/P的出现？3.我们将研究成果提交给了Journal“PLASTIC AND RECONCRECTIVE SURGERY”，目前正在印刷中。合作者：久野润（爱知学院大学口腔颌面外科第2讲座）外科学，助理教授）

项目成果

Jun Kuno: "Experimental Study on Cleft Lip and/or Palate in Transplantation of Fertilized Ovum Mice, - In the Case of Transplantation of Fertilized Ova of CL/P - Resistant C57BL/6 Strain Mice to Pseudopregnant CL/P-Prone A/J Strain Mice-"The Aichi-Gakuin

Jun Kuno：“受精卵小鼠移植中唇裂和/或腭裂的实验研究——以CL/P抗性C57BL/6品系小鼠的受精卵移植至假孕CL/P-Prone A/J为例

Jun Kuno,Natsume,Tsuyoshi Kawai: "Transplantation of Fertilized Ova CL/P-resistant C57BL/6 Srtain Mice to Pseudo-pregnant CL/P-prone A/J Strain Mice"PACSTIC AND RECONSTRUCTIVE SURGERY. (印刷中).

Jun Kuno、Natsume、Tsuyoshi Kawai：“将受精卵 CL/P 抗性 C57BL/6 小鼠移植到假妊娠 CL/P 倾向 A/J 品系小鼠”，PACSTIC 和重建手术。

久野淳: "マウス受精卵移植における口唇,口蓋裂発生に関する実験的研究-口唇,口蓋裂非発生系(C57BL/6系)マウス受精卵の易発生系(A/J系)マウスへの移植-"愛知学院大学歯学会誌. 36(4). 611-616 (1998)

Jun Kuno：《小鼠受精卵移植唇腭裂发育的实验研究——将唇腭裂非裂（C57BL/6系）小鼠受精卵移植到易感系（A/J系）小鼠中——》杂志爱知学院大学牙科学会 36(4) 611-616 (1998)。

Jun Kuno, Nagato Natsume, Tsuyoshi Kawai: "Transplantation of Fertilized Ova of CL/P-Resistant C57BL/6 Strain Mice to Pseudo-Pregnant CL/P-prone A/J Strain Mice"PLASTIC AND RECONSTRUCTIVE SURGERY. in press.

Jun Kuno、Nagato Natsume、Tsuyoshi Kawai：“将 CL/P 抗性 C57BL/6 品系小鼠的受精卵移植到假妊娠 CL/P 倾向 A/J 品系小鼠”整形和重建手术。

Jun Kuno, Nagato Natsume, Tsuyoshi Kawai: "Transplantation of Fertilized Ova of CL/P-resistant C57BL/6 Strain Mice to Pseudo-pregnant CL/P-prone A/J Strain Mice"PLASTIC AND RECONSTRUCTIVE SURGERY. (印刷中).

Jun Kuno、Nagato Natsume、Tsuyoshi Kawai：“将 CL/P 抗性 C57BL/6 品系小鼠的受精卵移植到假妊娠 CL/P 倾向的 A/J 品系小鼠”整形外科和重建手术。