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CONTROL OF SALIVARY SECRETION BY CENTRAL MECHANISMS OF BODY FLUID BALANCE AND DRINKING IN THE HYPOTHALAMUS

下丘脑体液平衡和饮水的中枢机制对唾液分泌的控制

基本信息

批准号：
09670076
负责人：
INENAGA Kiyotoshi
金额：
$ 2.3万
依托单位：
KYUSHU DENTAL COLLEGE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Increased plasma osmolarity incudes decreased secretion of saliva and mucus and then these decreased secretion causes thirst sensation. However, it is not clear a relationship underlying between central mechanism of body fluid balance and salivary secretion. A pile of recent studies reveal a central control system of water balance in the body, by mainly using a species of rodents. On the other hand, studies concerning to the mechanisms of salivary secretion have been accomplished by using big animals such as human beings, cows, sheep and dogs. The purpose of this study is to address how a central osmoreception is related to salivary secretion, by using rats which is a species that the central mechanism of body fluid balance has been well understood. We observed the time required to eat a certain weight of pellet and a volume of saliva secreted during the food intake. Then we evaluated how these values were changed with treatment of 24 hours dehydration, intraperitoneal injection of hypertonic saline (0.9 % and 5 %) and intracerebroventricular injection of hypertonic solution ( 1M NaCI, 0.9 M mannitol ). The secreted sa? iva was collected from a polyethylene tube which was cannulated to a duct of the parotid gland. The time required to eat a pellet prolonged with the intraperitoneal injection of 5 % NaCI and the intracerebroventricular injection of 1 M NaCI and O.9 M mannitol. The volume of salivary secretion during the period showed no change or increased a little. On the other hand, 24 hours dehydrated rats showed an increased volume and rate of salivary secretion. Taken from these results, it is suggested that acute administration of hypertonic solution activates osmoreceptors in the central nervous system and this activation decreases salivary secretion from the parotid glands. On the other hands, enhancement of salivary secretion after 24 hours dehydration may imply an involvement of several factors such as taste and tactile sense.

血浆渗透压增加导致唾液和粘液分泌减少，然后这些分泌减少导致口渴感。然而，体液平衡的中枢机制与唾液分泌之间的关系尚不清楚。最近的一系列研究主要通过一种啮齿类动物揭示了体内水平衡的中央控制系统。另一方面，利用人、牛、羊、狗等大型动物完成了有关唾液分泌机制的研究。本研究的目的是通过使用大鼠来解决中枢渗透感受与唾液分泌的关系，大鼠是体液平衡的中心机制已被充分了解的物种。我们观察了吃掉一定重量的颗粒所需的时间以及进食过程中分泌的唾液量。然后我们评估了24小时脱水、腹腔注射高渗盐水（0.9%和5%）和脑室内注射高渗溶液（1M NaCl、0.9M甘露醇）的处理如何改变这些值。分泌的sa？ iva 是从插入腮腺导管的聚乙烯管中收集的。腹腔注射5% NaCl和脑室内注射1M NaCl和0.9M甘露醇，吃颗粒所需的时间延长。期间唾液分泌量无变化或略有增加。另一方面，24小时脱水的大鼠表现出唾液分泌量和速率增加。从这些结果可以看出，急性施用高渗溶液会激活中枢神经系统中的渗透压感受器，并且这种激活会减少腮腺的唾液分泌。另一方面，脱水24小时后唾液分泌增加可能意味着味觉和触觉等多种因素的参与。