Analysis of pathophysiology in acute pancreatitis from the stand point of second attack theory

从二次发作学说分析急性胰腺炎的病理生理

• 批准号: 09470254
• 负责人: OGAWA Michio
• 金额: $ 5.7万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470254/
• 关键词: acute pancreatitis; SIRS; cytokine; organ dysfunction; infection; neutrophil; second attack; 重症度評価; scond attack; 臓器傷害

Acute pancreatitis is accompanied by destruction and digestion of tissues, causing hvpercytokinemia and hyperreactivity of leukocytes (macrophages and neutrophils) and vascular endothelia! cells. As one of the biological defense mechanisms in this condition, neutrophils infiltrate vital organs, such as lung, liver, and digestive organs. When acute pancreatitis is complicated by infection, hyperreactive macrophages release a large amount of proinflammatory cytokines that activate primed neutrophils as a second attack". Utilizing proteolytic enzymes and oxidant, neutrophils injure the infiltrated vital organs, causing cellular damage and dysfunction of vital organs distant from the pancreas. Multiple organ failure in acute pancreatitis with septic complications can develop, at least in part, by inflammatory cytokine and neutrophil activation.

急性胰腺炎伴随着组织的破坏和消化，导致高细胞分裂素血症和白细胞(巨噬细胞和中性粒细胞)和血管内皮细胞的高反应性！细胞。作为这种情况下的生物防御机制之一，中性粒细胞渗透到重要器官，如肺、肝脏和消化器官。当急性胰腺炎并发感染时，高反应的巨噬细胞释放大量的促炎细胞因子，激活中性粒细胞作为第二次攻击。利用蛋白水解酶和氧化剂，中性粒细胞损伤浸透的重要器官，导致细胞损伤和远离胰腺的重要器官功能障碍。急性胰腺炎合并败血症并发症的多器官衰竭可以至少部分地通过炎性细胞因子和中性粒细胞的激活而发生。

项目成果

Ogawa M.: "Systemic inflammatory response syndrome-a concept for avoiding organ dysfunction induced by a"Second Attack"" Surg Today. 28. 679-681 (1998)

小川 M.：“全身炎症反应综合征 - 避免“第二次发作”引起的器官功能障碍的概念”《今日外科》。

Ogawa M. et al.: "The Immure Consequences of Trauma, Shock and Sepsis" Monduzzi Editore (Bologna), 931-934 (1997)

Okawa M. 等人：“创伤、休克和脓毒症的不可控后果”Monduzzi Editore (博洛尼亚), 931-934 (1997)

Ogawa M: "Systemic inflammatory response syndrome-a concept for avoiding organ dysfunction induced by a "second attack"" Surg.Today. 28. 679-681 (1998)

小川 M：“全身炎症反应综合征 - 避免“第二次发作”引起的器官功能障碍的概念”Surg.Today。

小川道雄: "急性膵炎の重症化機序とサイトカイン" 今月の治療. 6. 86-92 (1998)

小川道雄：“急性胰腺炎的严重机制和细胞因子”本月的治疗。6. 86-92 (1998)。

Ikei S,et al.: "Blood concentrations of polymorphonuclear leukocyte elastase and interleukin-6 are indicators for the occurrence of multiple organ failures at the early stage of acute pancreatitis." J.Gastrogenterol.Hepatol.13. 1274-1283 (1998)

Ikei S等人：“多形核白细胞弹性蛋白酶和白细胞介素6的血液浓度是急性胰腺炎早期发生多器官衰竭的指标。”