GENOME ANALYSIS OF THEILERIA PARASITES
GENOME ANALYSIS OF THEILERIA PARASITES
批准号:
09044199
负责人:
SUGIMOTO Chihiro
金额:
$9.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for international Scientific Research
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
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英文摘要
This project was carried out to analyze genomes of Theileria parasites Eight hundred cDNA clones of Theileria parva was partially sequences to use as expressed sequence tags (ESTs). Some of them were mapped on chromosomes of T.parva. A bacterial artificial chromosome (BAC) library, each of which clones contained 50-200 kilobase pairs of T.parva chromosome fragments, was constructed.The library consisted of 3600 clones that theoretically covered entire T.parva genome. BAC clones that contained gene(s) essential for parasite growth including sporozoite surface protein were identified, which will be useful to analyze genome structures flanking these genes.4 chromosomes of T.sergenti were identified. Size of each chromosome and total genome size of this species was almost same as those of T.parva. Comparative mapping analysis of several homologous genes on T.parva and T.sergenti chromosomes revealed that syntenies among some of the genes are not conserved, which indicated difference of genome structures between these two Theileria species.Although further studies are required to determine whole chromosome structure of T.parva, the results of this project provide a basal information about genome structures of Theileria parasite by establishing BAC library, obtaining ESTs, and comparing two theilerial genomes.
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Sako, Y,et al.: "Molecular cloning and characterization of 23 kDa piroplasm surface proteins of Theileria sergenti and T.buffeli" International Journal for Parasitoloy. (In Press). (1999)
Sako, Y 等人:“Theileria sergenti 和 T.buffeli 23 kDa 梨质表面蛋白的分子克隆和表征”国际寄生虫杂志。
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通讯作者:
Iwasaki, T.et al.: "Differentiation and quantification of Theileria sergenti piroplasm types using type-specific monoclonal antibodies" Journal of Veterinary Medical Science. 60. 665-669 (1998)
Iwasaki, T.et al.:“使用类型特异性单克隆抗体对瑟氏泰勒虫梨原体类型进行区分和定量”《兽医医学科学杂志》。
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通讯作者:
Sako, Y, et al.: "Molecular cloning and characterization of 23 kDa piroplasm surface proteins of Theileria sergenti and T.buffeli" Journal of Protozoology Reaserch. in press. (1999)
Sako, Y 等人:“Theileria sergenti 和 T.buffeli 23 kDa 梨质表面蛋白的分子克隆和表征”原生动物学研究杂志。
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通讯作者:
Sako, Y., et al.: "Molecular cloning of a cysteine protease gene of Theileria sergenti." Journal of Veterinary Medical Science. in press. (1999)
Sako, Y. 等人:“谢氏泰勒虫半胱氨酸蛋白酶基因的分子克隆”。
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Kawazu,S: "Phylogenetic relationships of the binign Theileria species in cattle ans Asian buffalo based on the major piroplasm surface protein(p33-34)gene sequence." International Journal for Parasitology. (In Press). (1999)
Kawazu,S:“基于主要梨质表面蛋白 (p33-34) 基因序列的牛和亚洲水牛中的双种泰勒虫物种的系统发育关系。”
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共 13 条
Surveillance of human African trypanosomiases transmitted from domestic and wild animals and detection of virulence factors
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批准号:19255015
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$21.72万
-
财政年份:2007
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负责人:SUGIMOTO Chihiro
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依托单位:
Genome analysis of Theileria orientalis and its functional genomics
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批准号:17208026
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.2万
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财政年份:2005
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负责人:SUGIMOTO Chihiro
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依托单位:
Effects of oral treatment with plant-expressed cytokines for mucosal barrier formation and maturation
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批准号:15380208
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.05万
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财政年份:2003
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负责人:SUGIMOTO Chihiro
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依托单位:
Molecular epidemiological study on blood-borne protozoan parasites of small ruminants in China
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批准号:15405036
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.49万
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财政年份:2003
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负责人:SUGIMOTO Chihiro
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依托单位:
Plant expression of antigens of animal pathogens and its application for oral vaccination
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批准号:12556053
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
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负责人:SUGIMOTO Chihiro
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依托单位:
Molecular approach to analyze strategies of pathogens in wildlife for acuierement of new host
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批准号:11691164
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$7.49万
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财政年份:1999
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负责人:SUGIMOTO Chihiro
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依托单位:
PLANT EXPRESSIONS OF CYTOKINES AND IIST APPILICATIONS FOR ANIMAL DISEASE CONTROL
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批准号:10556067
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:1998
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负责人:SUGIMOTO Chihiro
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依托单位:
Molecular analysis of intraerythrocytic parasite population dinamics and acquirement of biological diversity
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批准号:10460126
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.32万
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财政年份:1998
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负责人:SUGIMOTO Chihiro
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依托单位:
ANALYSIS OF INTRACELLULAR ADAPTATION MECHANISMS OF PROTOZOAN PARASITES AND HOST ELIMINATION
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批准号:08456143
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.8万
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财政年份:1996
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负责人:SUGIMOTO Chihiro
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依托单位:
Molecular epidemiology of Theileria infections in Africa : Characterization of parasites of wild and domestic animals.
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批准号:07041119
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.31万
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财政年份:1995
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负责人:SUGIMOTO Chihiro
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依托单位:
DEVELOPMENT OF DNA PROBES FOR THE DIAGNOSIS OF HEMOPARASITE INFECTIONS.
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批准号:04556043
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$9.79万
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财政年份:1992
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负责人:SUGIMOTO Chihiro
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依托单位:
海外基金