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Imaging and Neural Circuits Core

成像和神经电路核心

基本信息

批准号：
10152569
负责人：
Charles Chavkin
金额：
$ 49.05万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10152569
关键词：
Animal Model Animals Behavior Behavior Control Brain Brain imaging Calcium Cells Cessation of life Code Communities Core Facility Cues Data Analyses Data Science Data Set Detection Development Drug abuse Educational workshop Endoscopy Epidemic Exposure to Funding Goals Image Infrastructure Laboratories Learning Light Logistics Methodology Modeling Molecular National Institute of Drug Abuse Neurons Opiate Addiction Opioid Opioid Analgesics Opsin Optics Pharmaceutical Preparations Photometry Pilot Projects Positioning Attribute Research Research Personnel Resolution Resources Rewards Role Sensory Site Stimulus Stress Substance abuse problem System Techniques Technology Therapeutic Uses Time Training United States United States National Institutes of Health Universities Washington Wireless Technology Work addiction awake base cell type computational neuroscience computerized tools data analysis pipeline illicit opioid imaging approach imaging facilities in vivo in vivo calcium imaging in vivo imaging innovative technologies insight meetings neural circuit neurotechnology novel strategies open data opioid abuse opioid use disorder optogenetics prescription opioid abuse ranpirnase relating to nervous system remote control sensor spatiotemporal tool two photon microscopy two-photon voltage

项目摘要

Summary: Opioid abuse is a major epidemic in the United States. In 2017 alone, abuse of prescription and illicit opioids resulted in over 60,000 deaths. The transition from therapeutic use of opioid pain relievers to destructive substance abuse occurs, in part, through maladaptive activation of mesocorticolimbic brain circuits. How these various sensory, reward, and stress neural circuits act at the systems, cellular and molecular levels remain poorly understood. As we work to advance our understanding of the development of opioid use disorder, we need to develop fundamental insights into how opioid circuits function in reward and aversion. In addition, we need to learn how these circuits are modulated, altered, and adapted over time in animal models of opioid addiction. We aim to leverage the diverse team of investigators at UW towards answering these questions. We propose to establish an advanced Imaging and Addiction Neural Circuits Core (INCC) to provide UW addiction researchers, neuroscientists, and the wider community with a suite of advanced neurotechnologies, for in vivo neural circuit perturbation and analysis. Beyond building and continually renewing a state-of-the-art imaging facility, a principal role of the Core will be to train the NIDA P30 Investigators in its uses in order to enhance the research of their NIDA funded projects. We will also disseminate these tools to the larger research community by providing on-site training. Collectivity, these resources will enable researchers at UW and beyond to identify and correct neurocircuit maladaptation observed in opioid addiction models.

总结：阿片类药物滥用是美国的一个主要流行病。仅在2017年，滥用处方药和非法阿片类药物导致超过六万人死亡从阿片类止痛药的治疗性使用到破坏性使用的转变药物滥用部分是由于中皮层边缘脑回路的不适应激活而发生的。如何将这些各种感觉、奖赏和压力神经回路在系统、细胞和分子水平上起作用，不太了解。随着我们努力推进对阿片类药物使用障碍发展的理解，我们我们需要对阿片类药物回路在奖励和厌恶中的作用有基本的了解。另外我们我们需要了解这些回路是如何在阿片类药物的动物模型中随着时间的推移而调节、改变和适应的成瘾我们的目标是利用UW多元化的调查团队来回答这些问题。我们建议建立一个先进的成像和成瘾神经回路核心（INCC），以提供UW成瘾研究人员、神经科学家和更广泛的社区，利用一套先进的神经技术，神经回路扰动和分析。除了构建和不断更新最先进的成像技术之外，核心的一个主要作用是培训NIDA P30调查人员使用该设施，以提高研究其NIDA资助的项目。我们还将向更大的研究社区传播这些工具提供现场培训。总的来说，这些资源将使研究人员在华盛顿大学和超越，以确定并纠正阿片类药物成瘾模型中观察到的神经回路适应不良。