University of Washington Center of Excellence in Opioid Addiction Research
华盛顿大学阿片类药物成瘾研究卓越中心
基本信息
- 批准号:10611870
- 负责人:
- 金额:$ 132.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimalsAnxiety DisordersAwardBehaviorBehavioralBrainBrain imagingCRISPR/Cas technologyCalcium SignalingCanis familiarisCellsCollaborationsCommunitiesComplexComputer AnalysisConfocal MicroscopyCoupledDSM-VDevelopmentDiseaseDrug AddictionDrug usageEducation and OutreachEducational workshopEndoscopyEnsureFiberFosteringFundingGene ExpressionGeneticGenetic TechniquesGoalsImageImaging DeviceInfrastructureInstitutionInvestigationLaboratoriesLightLinkMental DepressionMethodologyModernizationMolecularMolecular GeneticsMonitorMorphineMusNational Institute of Drug AbuseNeurobiologyNeuronsNeurosciencesOpiate AddictionOpioidPainParticipantPhotometryPhotonsPilot ProjectsPostdoctoral FellowProductivityQualifyingRattusReagentReceptor SignalingRecording of previous eventsReproducibilityResearchResearch PersonnelResolutionResource SharingResourcesRiskRodentRodent ControlScientistSelf AdministrationSubstance Use DisorderTechniquesTrainingTraining and EducationUnited States National Institutes of HealthUniversitiesViralViral GenesVisitVisualizationWashingtonaddictionarchive dataawakecomorbiditycomputational neurosciencecomputerized toolsdata analysis pipelinedesigndesign and constructiondrug abstinencedysphoriagenetic manipulationgenetic resourcegraduate studentimaging approachimaging geneticsin vivoinnovationinsightmeetingsmotivated behaviorneural circuitneuroimagingnovelnovel therapeuticsopen dataopioid useopioid use disorderoptogeneticsoutreachrecruitrelapse riskresearch studysensortooltwo photon microscopytwo-photonundergraduate studentvectorweb site
项目摘要
Overall Summary
The “University of Washington Center of Excellence in Opioid Addiction Research” is designed to provide
shared resources that would enhance efficiency and facilitate collaborative research for the study of the effects
of opioids on neural circuits with the goal of understanding opioid addiction mechanisms and developing novel
treatments for drug addiction. Center participants from 16 UW laboratories are using optogenetic control of
rodent behavior, in vivo neuroimaging of single cell calcium signals and other receptor signaling probes, viral
gene expression and CRISPR/cas9 manipulations to deconstruct and study opioid self-administration. This
group has a long-history of highly productive, collaborative, cutting-edge research and training that will be
strengthened by the shared resources provided by this award. The proposed Center would be comprised of
four components: The Administrative Core will coordinate resource utilization, organize monthly Research
Progress Meetings, organize training and outreach efforts. The Imaging and Neural Circuits Core would
develop shared resources for in vivo brain imaging in rats and mice using 1-Photon endoscopy, Inscopix
imaging, 2-Photon confocal microscopy, Spatial Light Modulation, fiber photometry and operant behaviors. The
Molecular Genetics Resource Core would provide DIO-AAV / CRISPR-cas9 / Canine Adeno Viral reagents,
develop new activity actuators and sensors and provide advanced training in cell-specific genetic manipulation
coupled with behavioral and computational analysis. A Pilot Project Core would enable participants and
trainees to initiate new projects utilizing the Imaging and Genetic Cores and would foster training and
collaborations within the Center laboratory groups and university community at large. The Center would
become a national neuroscience resource by providing training to visiting scientists, reagents for genetic
manipulation and novel actuators/sensors on request from investigators at other institutions. It will provide
workshops and summer courses for training advanced undergraduate and graduate students in optogenetics,
computational neuroscience, and viral design & construction techniques. All of these components would be
focused on understanding the changes in neural circuitry responsible for opioid addiction and on the
development of new therapeutic tools based on these insights.
整体总结
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.
通过在非依赖性 TH::Cre 大鼠腹侧被盖区过度表达 Oprk1 来概括酒精依赖性表型。
- DOI:10.1016/j.neuropharm.2023.109457
- 发表时间:2023
- 期刊:
- 影响因子:4.7
- 作者:Lepreux,Gaetan;Shinn,GraceE;Wei,Gengze;Suko,Azra;Concepcion,George;Sirohi,Sunil;SoonGo,Bok;Bruchas,MichaelR;Walker,BrendanM
- 通讯作者:Walker,BrendanM
Kappa-opioid receptor activation reinstates nicotine self-administration in mice.
Kappa-阿片受体激活可恢复小鼠尼古丁的自我给药。
- DOI:10.1016/j.addicn.2022.100017
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Gowrishankar,Raajaram;Gomez,Adrian;Waliki,Marie;Bruchas,MichaelR
- 通讯作者:Bruchas,MichaelR
A unique role for cAMP signaling in microglia during opioid tolerance and withdrawal.
阿片类药物耐受和戒断期间小胶质细胞中 cAMP 信号传导的独特作用。
- DOI:10.1038/s41386-023-01685-2
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Coffey,KevinR;Neumaier,JohnF
- 通讯作者:Neumaier,JohnF
Satb2 neurons in the parabrachial nucleus mediate taste perception.
- DOI:10.1038/s41467-020-20100-8
- 发表时间:2021-01-11
- 期刊:
- 影响因子:16.6
- 作者:Jarvie BC;Chen JY;King HO;Palmiter RD
- 通讯作者:Palmiter RD
A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice.
- DOI:10.7554/elife.81919
- 发表时间:2023-04-11
- 期刊:
- 影响因子:7.7
- 作者:Balsevich G;Petrie GN;Heinz DE;Singh A;Aukema RJ;Hunker AC;Vecchiarelli HA;Yau H;Sticht M;Thompson RJ;Lee FS;Zweifel LS;Chelikani PK;Gassen NC;Hill MN
- 通讯作者:Hill MN
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Charles Chavkin其他文献
Charles Chavkin的其他文献
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{{ truncateString('Charles Chavkin', 18)}}的其他基金
University of Washington Center of Excellence in Opioid Addiction Research
华盛顿大学阿片类药物成瘾研究卓越中心
- 批准号:
10394246 - 财政年份:2019
- 资助金额:
$ 132.76万 - 项目类别:
University of Washington Center of Excellence in Opioid Addiction Research
华盛顿大学阿片类药物成瘾研究卓越中心
- 批准号:
10152567 - 财政年份:2019
- 资助金额:
$ 132.76万 - 项目类别:
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