Pilot Project Core

试点项目核心

• 批准号: 10394250
• 负责人: Charles Chavkin
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394250
• 关键词: Address; Advisory Committees; Award; Dynorphins; Funding; Funding Mechanisms; Future; Heroin; Individual; Molecular Genetics; Morphine; National Institute of Drug Abuse; National Research Service Awards; Neurons; Opiate Addiction; Pilot Projects; Postdoctoral Fellow; Receptor Activation; Relapse; Research; Research Personnel; Research Support; Resources; Self Administration; Site; Stress; Suggestion; Training Programs; Universities; Washington; Withdrawal; base; craving; design; genetic resource; graduate student; high risk; imaging genetics; in vivo calcium imaging; innovation; kappa opioid receptors; member; novel; opioid use disorder; programs; ranpirnase; response; sensor

Pilot Project Summary The University of Washington Center of Excellence in Opioid Addiction Research would establish a pilot project program designed to support 2 new projects per year. Proposed pilot projects will be solicited annually from the NIDA P30 Investigators. These proposals would be ranked by the External Advisory Committee based on a simple set of criteria: Priority will be given to proposals that 1) address an aspect of opioid use disorder, 2) support young investigators, 3) utilize the Imaging and Molecular Genetics resources, and 4) emphasize innovation/high risk. Low priority will be given to proposals that supplement existing funding. We expect that some of the pilot project proposals will come from trainees supported by our NIDA-T32 DA 007278. Providing research support to fellows already having stipend support from the T32 or an individual NRSA award will leverage the Pilot Project funds and strengthen our training program. Based on these criteria, the top 2 projects will be selected and the applicants will be asked to expand their outlines to a 5-page description that includes specific aims, research plan and deliverables. These proposals will again be reviewed by the members of the External Advisory Committee who will provide constructive input. Once these suggestions are incorporated, the 2 proposals will be forwarded to NIDA Program for additional consideration prior to funding. Based on these criteria, two proposals have been selected in this initial submission. Pilot Project 1 describes studies proposed by Mr. Tim O'Neal, a graduate student working in Dr. Susan Ferguson's lab (Mr. O'Neal has stipend support from a NIDA F31 NRSA). This project would use in vivo calcium imaging to analyze responses and excitability changes in PFC neurons during heroin self-administration. Pilot Project 2 describes studies proposed by Dr. Antony Abraham, a postdoctoral fellow working in Dr. Charles Chavkin's lab. (Dr. Abraham has been supported by the UW's NIDA T32). His project would evaluate novel activity sensors designed to characterize kappa opioid receptor activation in PFC neurons during morphine-withdrawal induced dynorphin release. Stress-induced dynorphin release has been shown to promote a dysphoric response that triggers craving and relapse, but the mechanisms and sites of action have not yet been characterized. Future Pilot Projects will be initiated annually after review.

试点项目摘要 华盛顿大学阿片类药物成瘾研究卓越中心将建立一个试点项目 计划每年支持2个新项目。每年将向 NIDA P30调查员。这些建议将由外部咨询委员会根据 一套简单的标准：将优先考虑以下提案：1）解决阿片类药物使用障碍的一个方面，2） 支持年轻的研究人员，3）利用成像和分子遗传学资源，4）强调 创新/高风险。对补充现有资金的建议将给予较低优先。我们预计 一些试点项目的建议将来自我们的NIDA-T32 DA 007278支持的学员。提供 对已经从T32或个人NRSA奖获得津贴支持的研究员的研究支持将 利用试点项目资金，加强我们的培训计划。根据这些标准，前两个项目 将被选中，申请人将被要求将其大纲扩展到5页的描述，其中包括 具体目标、研究计划和成果。这些建议将再次由委员会成员审议。 外部咨询委员会将提供建设性意见。一旦这些建议被采纳， 2项提案将提交给NIDA计划，供其在资助之前进一步考虑。基于这些 根据这些标准，在首次提交的提案中选择了两个提案。试点项目1介绍了拟议的研究 作者是在苏珊·弗格森博士实验室工作的研究生蒂姆·奥尼尔先生（奥尼尔先生有助学金支持 NIDA F31 NRSA）。本计画将利用活体钙离子影像分析反应与兴奋性 海洛因自我给药过程中PFC神经元的变化。试点项目2描述了博士提出的研究。 安东尼亚伯拉罕，在查尔斯·查夫金博士实验室工作的博士后研究员。(Dr.亚伯拉罕一直 由UW的NIDA T32支持）。他的项目将评估新型活动传感器， 吗啡戒断诱导强啡肽释放过程中PFC神经元κ阿片受体激活 压力诱导的强啡肽释放已被证明会促进焦虑反应，从而引发渴望， 复发，但机制和网站的作用尚未确定。未来试点项目将 每年审查后启动。