PILOT PROJECTS CORE

项目总结及关键人员 发展试点项目、跨BETRNet试点项目和其他跨BETRNet活动 摘要：BETRNet开发研究计划(DRP)的总体目标是开发 针对Barrett‘s食管腺癌和食管腺癌的创新和多样化的治疗方法 从病因学到预防、筛查、诊断和 治疗学。DRP将提供1)财政支持，2)生物信息学支持，3)资源和4)智力 对试点研究项目和调查人员的监督和建议。用于开展先导研究的资金 项目对研究中心(研究中心)的持续发展和加强至关重要，因此 区域市政局将在第二至第五年每年为试验计划拨款11万元，每年为试验计划拨款4万元。 来自RC内部，每年为跨中心项目提供70,000美元。中心内和中心间试点项目 将由BETRNet指导委员会进行征求、审查和奖励，并进行评估 基于科学价值、影响、意义、创新、跨学科特征、翻译的标准 潜力，非常重视对加强和扩展BETRNet的贡献的潜力 项目以及发展为独立研究项目的潜力。此外，跨中心试点 资源和/或专业知识或与其他BETRNet研究中心或其他多机构的合作 合作小组。 用新的方法。对于个别基础或临床研究人员提出的有价值的建议， 领导小组将指定互补的翻译调查人员担任顾问。创新的 我们会继续吸纳本局内外的专业人士，并会在 癌症中心网站和国家BETRNet网站，其中各有一系列研究机会 RC项目将提供一份研究问题、资源、专业知识等清单，可用于 协同试点项目研究。 主要人员： 内森·A·伯杰医学博士 Amitabh Chak医学博士，MS Sanford Markowitz医学博士

PROJECT SUMMARY AND KEY PERSONNEL Developmental Pilot Projects, Cross BETRNet Pilot Projects, and Other Cross BETRNet Activities Summary: The overall objective of the BETRNet Developmental Research Program (DRP) is to develop innovative and diverse approaches to focus on Barrett's esophagus and esophageal adenocarcinoma translational research across the spectrum from etiology through prevention, screening, diagnostics, and therapeutics. The DRP will provide 1) Financial support, 2) Bioinformatic support 3) Resources and 4) Intellectual oversight and advice for pilot research projects and investigators. Funds for development of pilot research projects are critical to ongoing development and enhancement of the Research Center (RC) and accordingly the RC will allocate $110,000 per year in years 2-5 for pilot projects to be used $40,000 per year for pilot projects from within the RC and $70,000 per year for cross center projects. Within-center and Cross Center Pilot Projects will be solicited, reviewed and awarded by the BETRNet Steering Committee on a merit basis with evaluation criteria based on scientific merit, impact, significance, innovation, transdisciplinary characteristics, translational potential, with great significance attached to the potential for the contribution to enhance and extend BETRNet projects as well as the potential for developing into independent research projects. In addition, cross-center pilot projects will consider potential contribution of applications to increase sample size, provide complimentary skills, resources and/or expertise or collaborations with other BETRNet Research Centers or other multi-institutional cooperative groups. Emphasis will be placed on supporting new investigators as well as established investigators with new approaches. For meritorious proposals from individual basic or clinical investigators, the DRP leadership group will identify complementary translational investigators to serve as advisors. An innovative approach that we will continue to engage expertise from both inside and outside the RC will be to post on the Cancer Center website and the national BETRNet website, a series of Research Opportunities in which each RC project will provide a list of research questions, resources, expertise, etc. that will be available for collaborative pilot project research. Key Personnel: Nathan A. Berger, MD Amitabh Chak, MD, MS Sanford Markowitz, MD, PhD