AACR-TREC-NIH Think Tank Conference: Energy Balance and Cancer; Mechanisms and Me

描述（由申请人提供）：肥胖已达到全球流行病的比例，现在被认为是公共卫生的重大危机。癌症是与肥胖相关的许多共病病症之一，并且可能在病因学上与肥胖相关，在肥胖与结肠癌、绝经后乳腺癌、食管腺癌、子宫癌、肾细胞癌等之间确定了特别强的流行病学关系。该提案寻求资金，以支持AACR-TREC-NCI赞助的题为“能量平衡与癌症：机制和调解人”的智囊团会议，该会议将于2008年2月24日、25日和26日在弗吉尼亚州Lansdowne度假会议中心举行。 虽然有强有力的流行病学证据将肥胖与癌症联系起来，但这种关系的机制和介质以及它们的潜在相互作用尚未明确定义，因此限制了调节它们在癌症预防、进展和治疗中的作用的尝试。本次会议将研究肥胖作为能量平衡紊乱的表现，以及由此产生的将这些疾病与癌症联系起来的介质和机制。高优先讨论的主题包括肥胖、运动和热量限制与癌症的关系，以及连接以下各项的机制和介质：（1）胰岛素、生长因子和胰岛素抵抗与癌症;（2）前列腺素和类花生酸与癌症;（3）炎症和应激因子与癌症;（4）脂肪因子和脂肪组织产物与癌症;以及（5）肥胖与癌症的激素介质。会议的总体目标是（1）激发这些领域和相关领域专家之间的挑衅性智库审议，（2）更好地识别连接肥胖和癌症的潜在介质，（3）定义它们的作用和相互作用机制，（4）概述一个研究议程，以指导对这些关系的批判性调查;（5）以确定最有前途的候选人，作为标记物和潜在的目标，为实验室，临床和转化研究。

DESCRIPTION (provided by applicant): Obesity has reached global pandemic proportions and is now considered a major crisis in public health. Cancer is among the many comorbid conditions associated with, and probably etiologically related to obesity, with a particularly strong epidemiological relation identified between obesity and colon cancer, post menopausal breast cancer, esophageal adenocarcinoma, uterine cancer, renal cell cancer and others. This proposal seeks funding to support an AACR-TREC-NCI Sponsored Think Tank Conference entitled Energy Balance and Cancer; Mechanisms and Mediators to be held February 24, 25 and 26, 2008 at the Lansdowne Resort Conference Center, Lansdowne, Virginia. While there is strong epidemiologic evidence connecting obesity to cancer, the mechanisms and mediators of this relation as well as their potential interactions are not clearly defined thus limiting attempts to modulate their effects in cancer prevention, progression and therapy. This meeting will examine obesity as a manifestation of disordered energy balance and the resultant mediators and mechanisms connecting these disorders to cancer. High priority themes for discussion include the relation of Obesity, Exercise and Caloric Restriction to Cancer and Mechanisms and Mediators connecting (1) Insulin, Growth Factors and Insulin Resistance to Cancer; (2) Prostaglandins and Eicosanoids to Cancer; (3) Inflammatory and Stress Factors to Cancer; (4) Adipokines and Fat Tissue Products to Cancer and (5) Hormonal Mediators of Adiposity to Cancer. The overall goals of the meeting are (1) to stimulate a provocative think tank deliberation among experts in these and related fields, (2) to better identify potential mediators connecting obesity and cancer, (3) to define their mechanisms of actions and interactions, (4) to outline a research agenda to guide critical investigations of these relations and (5) to identify the most promising candidates to serve as markers and potential targets for both laboratory, clinical and translational research.