Broadband X-ray Fluorescence Emission Tomography

宽带 X 射线荧光发射断层扫描

• 批准号: 10159267
• 负责人: Patrick Jean La Riviere
• 金额: $ 53.52万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159267
• 关键词: 3-Dimensional; Algorithms; Animals; Attention; Biological; Calibration; Cathodes; Characteristics; Clinical Trials; Computer software; Cryopreservation; Custom; Diagnostic radiologic examination; Electronics; Electrons; Elements; Energy-Generating Resources; Fluorescence; Goals; Heavy Metals; Hour; Image; Imaging Device; Institutes; Joints; Letters; Maps; Mediating; Medicine; Metals; Methods; Microscopy; Monitor; Mus; Noise; Penetration; Pharmaceutical Preparations; Play; Power Sources; Radiation; Radiation Dose Unit; Radiation therapy; Radiosensitization; Reactive Oxygen Species; Resolution; Roentgen Rays; Role; Signal Transduction; Source; System; Techniques; Testing; Texture; Time; Tissue Sample; Tissues; Tube; Tumor Tissue; X-Ray Computed Tomography; absorption; attenuation; base; cancer therapy; chemotherapeutic agent; computerized data processing; data acquisition; design; detection platform; detector; flexibility; imaging probe; imaging study; imaging system; improved; in vivo; microCT; nano; nanoparticle; novel; preclinical study; radiation delivery; reconstruction; side effect; single photon emission computed tomography; study characteristics; tomography; tool

Abstract The goal of this proposed project is to develop an ultrahigh sensitivity, broadband X-ray fluorescence emission tomography (XFET) system. This system combines advanced CdTe X-ray imaging spectrometers assembled in a customized SPECT-like detection system design, and optimized source/filtering configurations to achieve a dramatically improved sensitivity to a broad range of metal elements that emit fluorescence x-rays of 5-100 keV. This system would be ideally suited for imaging heavier elements, such as Hf, Gd, Au and Pt with adequate tissue penetration for in vivo small animal studies. As a design target, we seek to construct an XFET system that is capable of imaging these heavy metals at a concentration of the order of 10 µg/ml in tissue equivalent, mouse-sized objects irradiated with X-ray sources of ~10 mA tube current and up to 150 kVp, and with an imaging time of around 1-2 hours and at a spatial resolution of a few hundred microns. This system would offer a unique imaging tool for guiding and monitoring the delivery of radiation-induced and nanoparticle-mediated radiation therapy.

摘要 该项目的目标是开发一种超高灵敏度、宽带的X射线荧光发射。 层析成像(XFET)系统。该系统结合了组装的先进的CdTe X射线成像光谱仪 在定制的类似SPECT的检测系统设计中，优化了信源/滤波配置，以实现 显著提高了对多种金属元素的敏感度，这些金属元素可发出5-100的荧光x射线 凯文。该系统非常适合于成像较重的元素，如Hf、Gd、Au和Pt 在活体小动物研究中有足够的组织穿透力。 作为一个设计目标，我们试图构建一个能够以一种速度成像这些重金属的XFET系统 经X射线源照射的组织等效鼠大小物体的浓度约为10微克/毫升 管电流约10 mA，最高可达150kVp，成像时间约为1-2小时，并在空间 几百微米的分辨率。该系统将为指导和监测提供一种独特的成像工具 辐射诱导和纳米粒子介导型放射治疗的传输。