Broadband X-ray Fluorescence Emission Tomography

宽带 X 射线荧光发射断层扫描

基本信息

批准号：
9751292
负责人：
Patrick Jean La Riviere
金额：
$ 48.69万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9751292
关键词：
3-Dimensional Algorithms Animals Attention Biological Calibration Cathodes Characteristics Clinical Trials Computer software Cryopreservation Custom Detection Diagnostic radiologic examination Electronics Electrons Elements Energy-Generating Resources Fluorescence Goals Heavy Metals Hour Image Imaging Device Institutes Joints Letters Maps Mediating Medicine Metals Methods Microscopy Monitor Mus Noise Penetration Pharmaceutical Preparations Play Power Sources Radiation Radiation Dose Unit Radiation therapy Radiation-Sensitizing Agents Reactive Oxygen Species Resolution Roentgen Rays Role Signal Transduction Source System Techniques Testing Texture Time Tissue Sample Tissues Tube Tumor Tissue X-Ray Computed Tomography absorption attenuation base cancer therapy chemotherapeutic agent computerized data processing data acquisition design detector flexibility imaging probe imaging study imaging system improved in vivo microCT nano nanoparticle novel preclinical study radiation delivery radiosensitizing reconstruction side effect single photon emission computed tomography study characteristics tomography tool

项目摘要

Abstract The goal of this proposed project is to develop an ultrahigh sensitivity, broadband X-ray fluorescence emission tomography (XFET) system. This system combines advanced CdTe X-ray imaging spectrometers assembled in a customized SPECT-like detection system design, and optimized source/filtering configurations to achieve a dramatically improved sensitivity to a broad range of metal elements that emit fluorescence x-rays of 5-100 keV. This system would be ideally suited for imaging heavier elements, such as Hf, Gd, Au and Pt with adequate tissue penetration for in vivo small animal studies. As a design target, we seek to construct an XFET system that is capable of imaging these heavy metals at a concentration of the order of 10 µg/ml in tissue equivalent, mouse-sized objects irradiated with X-ray sources of ~10 mA tube current and up to 150 kVp, and with an imaging time of around 1-2 hours and at a spatial resolution of a few hundred microns. This system would offer a unique imaging tool for guiding and monitoring the delivery of radiation-induced and nanoparticle-mediated radiation therapy.

抽象的该提议的项目的目的是发展超高灵敏度，宽带X射线荧光发射断层扫描（XFET）系统。该系统结合了组装的高级CDTE X射线成像光谱仪在定制的类似Spect的检测系统设计中，以及优化的源/过滤配置以实现对荧光X射线的广泛金属元件的敏感性极大地提高了灵敏度凯夫。该系统非常适合成像较重的元素，例如HF，GD，AU和PT 体内小动物研究的足够组织穿透。作为设计目标，我们试图构建一个能够在A中对这些重金属进行成像的XFET系统 X射线源辐射的组织等效的小鼠大小的物体中10 µg/ml的浓度〜10 mA管电流且最大150 kVp，成像时间约为1-2小时，在空间上分辨率为几百微米。该系统将为指导和监视提供独特的成像工具辐射诱导的和纳米粒子介导的放射疗法的递送。