Broadband X-ray Fluorescence Emission Tomography

宽带 X 射线荧光发射断层扫描

• 批准号: 9926880
• 负责人: Patrick Jean La Riviere
• 金额: $ 50.07万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926880
• 关键词: 3-Dimensional; Algorithms; Animals; Attention; Biological; Calibration; Cathodes; Characteristics; Clinical Trials; Computer software; Cryopreservation; Custom; Detection; Diagnostic radiologic examination; Electronics; Electrons; Elements; Energy-Generating Resources; Fluorescence; Goals; Heavy Metals; Hour; Image; Imaging Device; Institutes; Joints; Letters; Maps; Mediating; Medicine; Metals; Methods; Microscopy; Monitor; Mus; Noise; Penetration; Pharmaceutical Preparations; Play; Power Sources; Radiation; Radiation Dose Unit; Radiation therapy; Radiosensitization; Reactive Oxygen Species; Resolution; Roentgen Rays; Role; Signal Transduction; Source; System; Techniques; Testing; Texture; Time; Tissue Sample; Tissues; Tube; Tumor Tissue; X-Ray Computed Tomography; absorption; attenuation; base; cancer therapy; chemotherapeutic agent; computerized data processing; data acquisition; design; detector; flexibility; imaging probe; imaging study; imaging system; improved; in vivo; microCT; nano; nanoparticle; novel; preclinical study; radiation delivery; reconstruction; side effect; single photon emission computed tomography; study characteristics; tomography; tool

Abstract The goal of this proposed project is to develop an ultrahigh sensitivity, broadband X-ray fluorescence emission tomography (XFET) system. This system combines advanced CdTe X-ray imaging spectrometers assembled in a customized SPECT-like detection system design, and optimized source/filtering configurations to achieve a dramatically improved sensitivity to a broad range of metal elements that emit fluorescence x-rays of 5-100 keV. This system would be ideally suited for imaging heavier elements, such as Hf, Gd, Au and Pt with adequate tissue penetration for in vivo small animal studies. As a design target, we seek to construct an XFET system that is capable of imaging these heavy metals at a concentration of the order of 10 µg/ml in tissue equivalent, mouse-sized objects irradiated with X-ray sources of ~10 mA tube current and up to 150 kVp, and with an imaging time of around 1-2 hours and at a spatial resolution of a few hundred microns. This system would offer a unique imaging tool for guiding and monitoring the delivery of radiation-induced and nanoparticle-mediated radiation therapy.

抽象的 该项目的目标是开发一种超高灵敏度、宽带 X 射线荧光发射装置 断层扫描（XFET）系统。该系统结合了先进的CdTe X射线成像光谱仪组装而成 在定制的类似 SPECT 的检测系统设计中，以及优化的源/过滤配置来实现 对发射 5-100 荧光 X 射线的各种金属元素的灵敏度显着提高 keV。该系统非常适合对较重元素（例如 Hf、Gd、Au 和 Pt）进行成像 足够的组织渗透性用于体内小动物研究。 作为设计目标，我们寻求构建一个 XFET 系统，能够以较低的速度对这些重金属进行成像。 在用 X 射线源照射的组织等效、小鼠大小的物体中浓度约为 10 µg/ml 约 10 mA 管电流和高达 150 kVp，成像时间约为 1-2 小时，并且在空间 分辨率可达几百微米。该系统将提供独特的成像工具用于引导和监控 辐射诱导和纳米颗粒介导的放射治疗的实施。