Broadband X-ray Fluorescence Emission Tomography

摘要 该项目的目标是开发一种超高灵敏度、宽带的X射线荧光发射。 层析成像(XFET)系统。该系统结合了组装的先进的CdTe X射线成像光谱仪 在定制的类似SPECT的检测系统设计中，优化了信源/滤波配置，以实现 显著提高了对多种金属元素的敏感度，这些金属元素可发出5-100的荧光x射线 凯文。该系统非常适合于成像较重的元素，如Hf、Gd、Au和Pt 在活体小动物研究中有足够的组织穿透力。 作为一个设计目标，我们试图构建一个能够以一种速度成像这些重金属的XFET系统 经X射线源照射的组织等效鼠大小物体的浓度约为10微克/毫升 管电流约10 mA，最高可达150kVp，成像时间约为1-2小时，并在空间 几百微米的分辨率。该系统将为指导和监测提供一种独特的成像工具 辐射诱导和纳米粒子介导型放射治疗的传输。

Abstract The goal of this proposed project is to develop an ultrahigh sensitivity, broadband X-ray fluorescence emission tomography (XFET) system. This system combines advanced CdTe X-ray imaging spectrometers assembled in a customized SPECT-like detection system design, and optimized source/filtering configurations to achieve a dramatically improved sensitivity to a broad range of metal elements that emit fluorescence x-rays of 5-100 keV. This system would be ideally suited for imaging heavier elements, such as Hf, Gd, Au and Pt with adequate tissue penetration for in vivo small animal studies. As a design target, we seek to construct an XFET system that is capable of imaging these heavy metals at a concentration of the order of 10 µg/ml in tissue equivalent, mouse-sized objects irradiated with X-ray sources of ~10 mA tube current and up to 150 kVp, and with an imaging time of around 1-2 hours and at a spatial resolution of a few hundred microns. This system would offer a unique imaging tool for guiding and monitoring the delivery of radiation-induced and nanoparticle-mediated radiation therapy.