Broadband X-ray Fluorescence Emission Tomography

宽带 X 射线荧光发射断层扫描

• 批准号: 9984658
• 负责人: Patrick Jean La Riviere
• 金额: $ 37.08万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9984658
• 关键词: 3-Dimensional; Algorithms; Animals; Attention; Biological; Calibration; Cathodes; Characteristics; Clinical Trials; Computer software; Cryopreservation; Custom; Detection; Diagnostic radiologic examination; Electronics; Electrons; Elements; Energy-Generating Resources; Fluorescence; Goals; Heavy Metals; Hour; Image; Imaging Device; Institutes; Joints; Letters; Maps; Mediating; Medicine; Metals; Methods; Microscopy; Monitor; Mus; Noise; Penetration; Pharmaceutical Preparations; Play; Power Sources; Radiation; Radiation Dose Unit; Radiation therapy; Radiation-Sensitizing Agents; Reactive Oxygen Species; Resolution; Roentgen Rays; Role; Signal Transduction; Source; System; Techniques; Testing; Texture; Time; Tissue Sample; Tissues; Tube; Tumor Tissue; X-Ray Computed Tomography; absorption; attenuation; base; cancer therapy; chemotherapeutic agent; computerized data processing; data acquisition; design; detector; flexibility; imaging probe; imaging study; imaging system; improved; in vivo; microCT; nano; nanoparticle; novel; preclinical study; radiation delivery; radiosensitizing; reconstruction; side effect; single photon emission computed tomography; study characteristics; tomography; tool

Abstract The goal of this proposed project is to develop an ultrahigh sensitivity, broadband X-ray fluorescence emission tomography (XFET) system. This system combines advanced CdTe X-ray imaging spectrometers assembled in a customized SPECT-like detection system design, and optimized source/filtering configurations to achieve a dramatically improved sensitivity to a broad range of metal elements that emit fluorescence x-rays of 5-100 keV. This system would be ideally suited for imaging heavier elements, such as Hf, Gd, Au and Pt with adequate tissue penetration for in vivo small animal studies. As a design target, we seek to construct an XFET system that is capable of imaging these heavy metals at a concentration of the order of 10 µg/ml in tissue equivalent, mouse-sized objects irradiated with X-ray sources of ~10 mA tube current and up to 150 kVp, and with an imaging time of around 1-2 hours and at a spatial resolution of a few hundred microns. This system would offer a unique imaging tool for guiding and monitoring the delivery of radiation-induced and nanoparticle-mediated radiation therapy.

摘要 本项目的目标是开发一种灵敏度高、宽频带的X射线荧光发射 X射线断层扫描（XFET）系统。该系统结合了先进的CdTe X射线成像光谱仪组装 在定制的类SPECT检测系统设计中，以及优化的源/滤波配置，以实现 对发射5-100 nm荧光X射线的宽范围金属元素的灵敏度显著提高 凯该系统将理想地适合于成像较重的元素，例如Hf、Gd、Au和Pt， 对于体内小动物研究而言，组织渗透充分。 作为一个设计目标，我们寻求构建一个XFET系统，能够成像这些重金属在 在组织当量、用X射线源照射的小鼠大小物体中的浓度约为10 µg/ml 约10 mA管电流和高达150 kVp，成像时间约为1-2小时，空间分辨率约为100 nm。 分辨率达到几百微米。该系统将提供一种独特的成像工具， 放射诱导和纳米粒子介导的放射治疗的递送。