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Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk

认知衰老和阿尔茨海默病风险中的脑血管阻力

基本信息

批准号：
10161741
负责人：
Daniel A Nation
金额：
$ 48.78万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10161741
关键词：
Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid beta-Protein Analysis of Covariance Atrophic Biological Markers Blood Blood Circulation Blood Vessels Brain Brain region Brain scan Breathing Carbon Dioxide Cerebrovascular Circulation Cerebrovascular Disorders Cerebrum Cognition Cognitive Cognitive aging Communities Cross-Sectional Studies Dementia Development Diffusion Magnetic Resonance Imaging Elderly Exhibits Functional Magnetic Resonance Imaging Future Hypercapnia Hypocapnia Immunoprecipitation Impaired cognition Intervention Link Longitudinal Studies Magnetic Resonance Imaging Measures Medicine Methodology Microvascular Dysfunction Modeling Monitor Nature Neurocognitive Deficit Neuropsychology Participant Pathway interactions Performance Peripheral Phenotype Plasma Reporting Resistance Rest Risk Assessment Role Spin Labels Stimulus Structure Taxus Vascular resistance Work arterial stiffness brain dysfunction cerebral atrophy cerebrovascular follow-up indexing insight longitudinal analysis method development novel novel strategies pressure statistics treatment response vascular cognitive impairment and dementia vascular contributions white matter

项目摘要

Project Summary The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.

项目摘要这项研究将探讨脑血管功能障碍在早期阶段的作用，神经认知下降，在认知的任何明显变化之前。具体而言，我们将研究有患阿尔茨海默病风险的认知正常的老年人显示出增加的脑血管阻力。我们还将研究如何增加脑血管阻力与脑功能障碍使用功能脑扫描。最后，我们将研究认知正常的老年人是否存在较高的脑血管阻力，预测在两年的随访期内发生轻微的认知能力下降。