Endothelial progenitor cells and neurovascular injury in the aging brain

衰老大脑中的内皮祖细胞和神经血管损伤

• 批准号: 10187482
• 负责人: Daniel A Nation
• 金额: $ 69.01万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187482
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease pathology; Amyloid; Blood Circulation; Blood Vessels; Brain; Brain Injuries; CD34 gene; Cell Aging; Cell Count; Cell Culture Techniques; Cells; Cerebrospinal Fluid; Cerebrum; Clinical; Cognition; Cognitive; Colony-forming units; Elderly; Exhibits; Flow Cytometry; Functional Magnetic Resonance Imaging; Functional disorder; Homing; Impaired cognition; In Vitro; Injury; Interleukin-8; Investigation; Lesion; Link; Longitudinal Studies; Magnetic Resonance Imaging; Neurocognitive; Neurons; Neuropsychology; Pathology; Reserve Cell; Risk; Risk Assessment; Risk Factors; Role; Signal Transduction; Site; Stains; Stroke; Structure; Therapeutic; Time; Vascular Diseases; White Matter Hyperintensity; age related; aging brain; angiogenesis; attenuation; beta-Galactosidase; brain dysfunction; cell injury; cerebral atrophy; cerebral hypoperfusion; cerebral microbleeds; cerebrovascular; cognitive function; dementia risk; endothelial stem cell; hypoperfusion; innovation; neurovascular; neurovascular injury; protective factors; senescence; stem cell function; stem cell proliferation; vascular cognitive impairment and dementia; vascular factor; vascular risk factor

Project Summary The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell function relates to neurovascular dysfunction, brain injury and cognitive decline.

项目概要 拟议的研究将调查内皮祖细胞在神经血管功能障碍和 传统血管风险水平较低且认知基线正常的老年人认知能力下降 功能。具体来说，我们将研究内皮祖细胞增殖和衰老是否发生变化 可以预测认知能力下降、脑血管病变以及大脑结构和功能连接。我们将 还研究内皮祖细胞培养物的分泌因子，以更好地了解祖细胞如何 功能与神经血管功能障碍、脑损伤和认知能力下降有关。