认知衰老和阿尔茨海默病风险中的脑血管阻力-猫眼课题宝

认知衰老和阿尔茨海默病风险中的脑血管阻力

批准号：

10605190

负责人：

Daniel A Nation

金额：

$0.0万

依托单位：

UNIVERSITY OF CALIFORNIA-IRVINE

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-08-01 至 2023-08-01

来源：

https://reporter.nih.gov/project-details/10605190

关键词：

Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid beta-Protein Analysis of Covariance Atrophic Biological Markers Blood Blood Pressure Blood Vessels Brain Brain region Brain scan Breathing Carbon Dioxide Cerebrovascular Circulation Cerebrovascular Disorders Cerebrum Circulation Cognition Cognitive Cognitive aging Communities Cross-Sectional Studies Dementia Development Diffusion Magnetic Resonance Imaging Elderly Exhibits Functional Magnetic Resonance Imaging Future Hypercapnia Hypocapnia Immunoprecipitation Impaired cognition Intervention Link Longitudinal Studies Magnetic Resonance Imaging Mass Spectrum Analysis Measures Medicine Methodology Microvascular Dysfunction Modeling Monitor Nature Neuroanatomy Neurocognitive Deficit Neuropsychology Organ Participant Pathway interactions Performance Peripheral Phenotype Plasma Reporting Resistance Rest Risk Assessment Role Stimulus Taxus Vascular resistance Work arterial spin labeling arterial stiffness brain dysfunction brain magnetic resonance imaging cerebral atrophy cerebrovascular follow-up indexing insight longitudinal analysis method development novel novel strategies pressure statistics treatment response vascular cognitive impairment and dementia vascular contributions white matter

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英文摘要

Project Summary The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.

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