Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk

项目摘要 这项研究将探讨脑血管功能障碍在早期阶段的作用， 神经认知下降，在认知的任何明显变化之前。具体而言，我们将研究 有患阿尔茨海默病风险的认知正常的老年人显示出增加的脑血管阻力。我们 还将研究如何增加脑血管阻力与脑功能障碍使用功能脑 扫描。最后，我们将研究认知正常的老年人是否存在较高的脑血管阻力， 预测在两年的随访期内发生轻微的认知能力下降。

Project Summary The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.