Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk

项目摘要 这项拟议的研究将调查脑血管功能障碍在脑血管疾病早期阶段的作用 神经认知衰退，在认知发生任何明显变化之前。具体来说，我们会研究是否 认知正常的老年人有患阿尔茨海默病的风险，表现为脑血管阻力增加。我们 我还将利用功能性大脑研究脑血管阻力增加与脑功能障碍之间的关系 扫描。最后，我们将调查认知正常的老年人是否存在较高的脑血管阻力 预测在两年的随访时间间隔内出现轻微的认知能力下降。

Project Summary The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.