Endothelial progenitor cells and neurovascular injury in the aging brain

衰老大脑中的内皮祖细胞和神经血管损伤

• 批准号: 10006097
• 负责人: Daniel A Nation
• 金额: $ 64.17万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006097
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease pathology; Amyloid; Blood Circulation; Blood Vessels; Brain; Brain Injuries; CD34 gene; Cell Aging; Cell Count; Cell Culture Techniques; Cell physiology; Cells; Cerebrospinal Fluid; Cerebrum; Clinical; Cognition; Cognitive; Colony-forming units; Elderly; Exhibits; Flow Cytometry; Functional Magnetic Resonance Imaging; Functional disorder; Homing; Impaired cognition; In Vitro; Injury; Interleukin-8; Investigation; Lesion; Link; Longitudinal Studies; Magnetic Resonance Imaging; Neurocognitive; Neurons; Neuropsychology; Pathology; Reserve Cell; Risk; Risk Assessment; Risk Factors; Role; Signal Transduction; Site; Stains; Stroke; Structure; Therapeutic; Time; Vascular Diseases; White Matter Hyperintensity; age related; aging brain; angiogenesis; attenuation; beta-Galactosidase; brain dysfunction; cell injury; cerebral atrophy; cerebral hypoperfusion; cerebral microbleeds; cerebrovascular; cognitive function; dementia risk; endothelial stem cell; hypoperfusion; innovation; neurovascular; neurovascular injury; protective factors; senescence; stem cell proliferation; stem cells; vascular cognitive impairment and dementia; vascular factor; vascular risk factor

Project Summary The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell function relates to neurovascular dysfunction, brain injury and cognitive decline.

项目摘要 这项研究将探讨内皮祖细胞在神经血管功能障碍中的作用， 具有低水平传统血管风险和正常基线认知能力的老年人的认知能力下降 功能具体来说，我们将研究内皮祖细胞增殖和衰老的变化是否 是认知能力下降、脑血管病变以及脑结构和功能连通性的预测指标。我们将 我还研究了内皮祖细胞培养物中的分泌因子，以更好地了解祖细胞 功能与神经血管功能障碍、脑损伤和认知能力下降有关。