衰老大脑中的内皮祖细胞和神经血管损伤-猫眼课题宝

衰老大脑中的内皮祖细胞和神经血管损伤

批准号：

10006097

负责人：

Daniel A Nation

金额：

$64.17万

依托单位：

UNIVERSITY OF CALIFORNIA-IRVINE

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-09-01 至 2024-05-31

来源：

https://reporter.nih.gov/project-details/10006097

关键词：

Address Alzheimer&apos s Disease Alzheimer&apos s disease pathology Amyloid Blood Circulation Blood Vessels Brain Brain Injuries CD34 gene Cell Aging Cell Count Cell Culture Techniques Cell physiology Cells Cerebrospinal Fluid Cerebrum Clinical Cognition Cognitive Colony-forming units Elderly Exhibits Flow Cytometry Functional Magnetic Resonance Imaging Functional disorder Homing Impaired cognition In Vitro Injury Interleukin-8 Investigation Lesion Link Longitudinal Studies Magnetic Resonance Imaging Neurocognitive Neurons Neuropsychology Pathology Reserve Cell Risk Risk Assessment Risk Factors Role Signal Transduction Site Stains Stroke Structure Therapeutic Time Vascular Diseases White Matter Hyperintensity age related aging brain angiogenesis attenuation beta-Galactosidase brain dysfunction cell injury cerebral atrophy cerebral hypoperfusion cerebral microbleeds cerebrovascular cognitive function dementia risk endothelial stem cell hypoperfusion innovation neurovascular neurovascular injury protective factors senescence stem cell proliferation stem cells vascular cognitive impairment and dementia vascular factor vascular risk factor

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英文摘要

Project Summary The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell function relates to neurovascular dysfunction, brain injury and cognitive decline.

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