Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk

项目概要 拟议的研究将调查脑血管功能障碍在早期阶段的作用 在认知发生任何明显变化之前，神经认知能力下降。具体来说，我们将研究是否 认知能力正常、有阿尔茨海默病风险的老年人表现出脑血管阻力增加。我们 还将利用功能性大脑研究脑血管阻力增加与脑功能障碍之间的关系 扫描。最后，我们将研究认知正常的老年人是否存在较高的脑血管阻力 预测两年随访期间认知能力会出现微妙的下降。

Project Summary The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.