Endothelial progenitor cells and neurovascular injury in the aging brain
衰老大脑中的内皮祖细胞和神经血管损伤
基本信息
- 批准号:10617818
- 负责人:
- 金额:$ 63.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAmyloidAmyloidosisBlood VesselsBrainBrain InjuriesCD34 geneCell AgingCell CountCell Culture TechniquesCellsCerebrospinal FluidCerebrumCirculationClinicalCognitionCognitiveColony-forming unitsDementiaElderlyExhibitsFlow CytometryFunctional disorderHomingImpaired cognitionIn VitroInjuryInterleukin-8InvestigationLesionLinkLongitudinal StudiesNeurocognitiveNeuronsNeuropsychologyPathologyPerfusionProliferatingProteinsReserve CellRiskRisk AssessmentRisk FactorsRoleSignal TransductionSiteStainsStrokeTherapeuticTimeVascular DiseasesWhite Matter Hyperintensityage relatedaging brainangiogenesisattenuationbeta-Galactosidasebrain dysfunctionbrain magnetic resonance imagingbrain volumecell injurycerebral atrophycerebral microbleedscerebrovascular lesioncognitive functiondementia riskendothelial stem cellhypoperfusioninnovationneurovascularneurovascular injuryprotective factorsrepairedsenescencestem cell functionstem cell proliferationvascular cognitive impairment and dementiavascular factorvascular risk factor
项目摘要
Project Summary
The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and
cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive
function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence
are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will
also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell
function relates to neurovascular dysfunction, brain injury and cognitive decline.
项目摘要
这项拟议的研究将探讨内皮祖细胞在神经血管功能障碍和
低水平传统血管风险和正常基线认知的老年人认知能力下降
功能。具体地说,我们将研究内皮祖细胞增殖和衰老的变化
预示着认知功能减退、脑血管损伤以及结构和功能脑连接。我们会
还要研究内皮祖细胞培养中的分泌因子,以更好地了解祖细胞如何
功能与神经血管功能障碍、脑损伤和认知能力下降有关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Daniel A Nation', 18)}}的其他基金
Endothelial progenitor cells and neurovascular injury in the aging brain
衰老大脑中的内皮祖细胞和神经血管损伤
- 批准号:
10408110 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk
认知衰老和阿尔茨海默病风险中的脑血管阻力
- 批准号:
10161741 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Endothelial progenitor cells and neurovascular injury in the aging brain
衰老大脑中的内皮祖细胞和神经血管损伤
- 批准号:
9802782 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk
认知衰老和阿尔茨海默病风险中的脑血管阻力
- 批准号:
10027264 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Endothelial progenitor cells and neurovascular injury in the aging brain
衰老大脑中的内皮祖细胞和神经血管损伤
- 批准号:
10006097 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Endothelial progenitor cells and neurovascular injury in the aging brain
衰老大脑中的内皮祖细胞和神经血管损伤
- 批准号:
10187482 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk
认知衰老和阿尔茨海默病风险中的脑血管阻力
- 批准号:
10605190 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别:
Cerebrovascular resistance in cognitive aging and Alzheimer's disease risk
认知衰老和阿尔茨海默病风险中的脑血管阻力
- 批准号:
10394910 - 财政年份:2019
- 资助金额:
$ 63.31万 - 项目类别: