Endothelial progenitor cells and neurovascular injury in the aging brain

项目摘要 这项拟议的研究将探讨内皮祖细胞在神经血管功能障碍和 低水平传统血管风险和正常基线认知的老年人认知能力下降 功能。具体地说，我们将研究内皮祖细胞增殖和衰老的变化 预示着认知功能减退、脑血管损伤以及结构和功能脑连接。我们会 还要研究内皮祖细胞培养中的分泌因子，以更好地了解祖细胞如何 功能与神经血管功能障碍、脑损伤和认知能力下降有关。

Project Summary The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell function relates to neurovascular dysfunction, brain injury and cognitive decline.