Cellular Networks in Cancer Program

细胞网络在癌症(NC)计划是一个科学丰富，合作和富有成效的研究 项目由Melanie Cobb博士和Ralph DeBerardinis博士共同领导。数控计划的愿景是 促进细胞间网络和细胞内网络对癌症的基础知识 开始、肿瘤发生和转移，然后将这些发现转化为癌症的新方法 预防和治疗。Cnc的首要科学目标是促进发现这些微扰是如何 细胞网络有助于改变组织生理并促进癌症。该数控程序提供了一种 高度互动的研究环境，充分利用德克萨斯大学西南医学中心(UTSW) 基础科学发现的悠久传统，并促进将这些发现转化为 临床肿瘤学中新的生物标记物、诊断技术和治疗干预的开发- 特别是与SCCC集水区相关的恶性肿瘤(例如肺癌和肾癌)。这个 计划的结构是有目的地设计的，以促进跨学科、计划内和计划间的 以交付变革性发现为目标的合作。为了实现这一目标，联合领导人 建立了四个充满活力和协作性的子计划，故意与计划的优势保持一致 与癌症组织内稳态紊乱状态有关的成员和特异性：(1)信号与细胞 生物学，(2)表观遗传学和基因调控，(3)免疫生物学，(4)新陈代谢。每个子程序都是 由一位因其科学、指导和合作精神而备受尊敬的研究人员指导。这个 子方案结构和活动直接促进了令人振奋的新合作项目，如 肾癌中的孢子。Cnc程序由59名基础、计算和内科科学家组成 来自德克萨斯大学西南医学中心的19个科室和中心。中国计算机网络中心的七名成员是霍华德 休斯医学研究所的调查人员。每年通过同行评审直接资助美国计算机控制中心项目的资金为1930万美元 2019年。这与2014年的数据相比增加了380万美元，这些数据进行了调整，以符合 修订了NCI指南。NCI的资金也同样从2014年的300万美元增加到2019年的390万美元。计划 自2014年以来，成员撰写了750份出版物：14%代表计划内工作，34%是 计划间协作中，32%是机构间协作，37%是影响因子为≥10的期刊。 NC计划成员严重依赖所有六个CCSG共享资源-特别是活细胞成像 和组织管理--以促进他们的科学目标。数控程序的成功有以下几点支持 SCCC强大的基础设施，并基于该计划在计算机控制系统成员和 子计划，以及与其他SCCC研究计划成员和外部合作者。

The Cellular Networks in Cancer (CNC) Program is a scientifically rich, collaborative, and productive research program co-led by Melanie Cobb, PhD, and Ralph DeBerardinis, MD, PhD. The vision of the CNC Program is to advance the fundamental knowledge of both intercellular and intracellular networks that contribute to cancer initiation, tumorigenesis, and metastasis, then to translate these findings into novel approaches to cancer prevention and therapy. CNC’s overarching scientific goal is to promote discoveries in how perturbation in these cellular networks contribute to altered tissue physiology and promote cancer. The CNC Program provides a highly interactive research environment that capitalizes on the UT Southwestern Medical Center’s (UTSW) longstanding tradition of basic science discoveries and fosters translation of these discoveries into the development of new biomarkers, diagnostic technologies, and therapeutic interventions in clinical oncology- especially malignancies relevant to the SCCC catchment area (e.g., cancer of the lung and kidney). The program’s structure is purposefully designed to stimulate interdisciplinary intra- and interprogrammatic collaborations with the objective of delivering transformative discoveries. To accomplish this, the Co-Leaders established four vibrant and synergistic subprograms that deliberately align with the strengths of program members and specifically relate to states of perturbed tissue homeostasis in cancer: (1) Signaling and Cell Biology, (2) Epigenetics and Gene Regulation, (3) Immunobiology, and (4) Metabolism. Each subprogram is directed by an investigator who is highly respected for his or her science, mentoring, and collaborative spirit. The subprogram structure and activities have directly contributed to exciting new collaborative projects such as the SPORE in Kidney Cancer. The CNC Program is composed of 59 basic, computational, and physician-scientists from 19 departments and centers at UT Southwestern Medical Center. Seven members of the CNC are Howard Hughes Medical Institute investigators. Annual direct peer-reviewed funding to the CNC Program was $19.3M in 2019. This represents an increase of $3.8M as compared with 2014 data, which were adjusted to conform to revised NCI guidelines. NCI funding has likewise increased from $3M in 2014 to $3.9M in 2019. Program members have authored 750 publications since 2014: 14% represent intraprogrammatic work, 34% are interprogrammatic collaborations, 32% are inter-institutional, and 37% are in journals with an impact factor ≥ 10. CNC Program members are heavily reliant upon all six CCSG Shared Resources—especially Live Cell Imaging and Tissue Management—in furtherance of their scientific goals. The CNC Program’s success is supported by SCCC’s strong infrastructure and grounded in the program’s solid interactions among CNC members and the subprograms, as well as with other SCCC Research Program members and external collaborators.