Administration Core

摘要：管理核心 自2016年以来，北卡罗来纳州立大学(NCSU)帮助扩大了GenomeTrakr计划在全国 并在全球范围内针对世界范围内食源性疾病的一些主要原因。以及表演 除了先进的分子技术和数据分析，研究人员还提供了最先进的培训 面向世界各地的学生和专业人士。到目前为止，NCSU GenomeTrakr实验室已经产生了3328个 从多种来源分离的细菌病原体的WGS图谱。这包括1,127个WGS配置文件 在过去的三年里，来自美国以外的9个国家的细菌分离。他们还培训了23名学生 和来自10个国家的专业人士，这导致了GenomeTrakr计划的11份原创出版物 由调查人员及其美国和国际受训人员共同撰写的同行评议期刊上的数据。 行政核心的主要目标是确保根据拟议的 以协调、高效的方式采取行动。因此，具体目标如下。目标1：提供 与国家和国际机构合作，发挥领导作用，完成拟议目标。这个 调查人员将提供强有力的领导，以确保有效的行政和财政管理。强壮 领导力还将有助于促进这一全球网络成员之间的新的和现有的互动， 进而将通过以下方式扩展WGS配置文件和随附的元数据的GenomeTrakr数据库 从国家和国际合作者那里收到的分离株和DNA。调查人员具有以下经验： 参与外部资助的项目，在项目截止日期前完成，并向资助机构提供进度报告 经纪公司。目标2：提供一个框架，用知识教育和装备未来的监测工作人员 和WGS分析所需的技能。国立中山大学人口健康与病理生物学系 调查实验室所在的兽医学院是世界卫生组织 (世卫组织)AMR和One Health协作中心。在这种情况下，该部门执行各种 促进全球食源性病原体和AMR监测的活动，从能力建设到加强 综合监测食源性细菌的耐药性，为全球提供技术支持 世卫组织成员国之间的数据共享和知识传播。调查人员将利用他们的 在监控协议、先进的分子技术和数据分析方面拥有丰富的领导经验， 以及他们作为世卫组织AMR和One Health合作中心的地位，以在美国和全球建设能力 通过对学生和专业人员进行世界级的培训。预期结果：调查人员是 致力于完成GenomeTrakr的使命并将标准化监控系统扩展到整个 环球网。通过在国家和国际地点建立新的和现有的伙伴关系和建设能力，这 这项工作将帮助公共卫生机构跟踪新菌株的出现，遏制食源性病毒的分布 减少美国和全球食源性疾病的负担。

Summary: Admin Core Since 2016, North Carolina State University (NCSU) has helped expand the GenomeTrakr program on a national and global scale to target some of the leading causes of foodborne illnesses worldwide. As well as performing advanced molecular techniques and data analysis, the investigators have also provided state-of-the-art training for students and professionals worldwide. To date, NCSU GenomeTrakr laboratories have generated 3,328 WGS profiles of bacterial pathogens isolated from multiple sources. This includes WGS profiles of 1,127 bacterial isolates from 9 countries outside the US over the last three years. They have also trained 23 students and professionals from 10 countries, which has led to 11 original publications of GenomeTrakr program data in peer-reviewed journals coauthored by the investigators and their US and international trainees. The major objective of the Administrative Core is to ensure all activities are completed according to the proposed approach in a coordinated, efficient manner. Accordingly, the specific aims are as follows. Aim 1: Provide leadership to complete the proposed aims in collaboration with national and international institutions. The investigators will provide strong leadership to ensure effective administration and fiscal management. Strong leadership will also help foster new and existing interactions between the members of this global network, which in turn will extend the GenomeTrakr database of WGS profiles and accompanying metadata by incorporating isolates and DNA received from national and international collaborators. The investigators have experience in working on extramural funded projects, meeting project deadlines, and providing progress reports to funding agencies. Aim 2: Provide a framework to educate and equip the future surveillance workforce with the knowledge and skills needed for WGS analysis. The Department of Population Health and Pathobiology at the NCSU College of Veterinary Medicine, where the investigating laboratories are located, is a World Health Organization (WHO) Collaborating Center for AMR and One Health. Under this status, the department performs a variety of activities to advance global foodborne pathogen and AMR surveillance, from capacity building to strengthen integrated surveillance of drug resistance in foodborne bacteria, to providing technical support such as global data sharing and knowledge dissemination among WHO member states. The investigators will leverage their extensive leadership experience in surveillance protocols, advanced molecular techniques and data analysis, and their status as a WHO Collaborating Center for AMR and One Health to build capacity in the US and globally through world-class training for students and professionals. Expected Outcomes: The investigators are committed to fulfilling the GenomeTrakr mission and expanding standardized surveillance systems across the globe. Through new and existing partnerships and building capacity in national and international locations, this work will help public health agencies track the emergence of new strains, curb the distribution of foodborne pathogens and reduce the burden of foodborne illnesses in the US and globally.