Administration Core

行政核心

• 批准号: 10175628
• 负责人: Siddhartha Thakur
• 金额: $ 2.81万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10175628
• 关键词: Administration; Core

Summary: Admin Core Since 2016, North Carolina State University (NCSU) has helped expand the GenomeTrakr program on a national and global scale to target some of the leading causes of foodborne illnesses worldwide. As well as performing advanced molecular techniques and data analysis, the investigators have also provided state-of-the-art training for students and professionals worldwide. To date, NCSU GenomeTrakr laboratories have generated 3,328 WGS profiles of bacterial pathogens isolated from multiple sources. This includes WGS profiles of 1,127 bacterial isolates from 9 countries outside the US over the last three years. They have also trained 23 students and professionals from 10 countries, which has led to 11 original publications of GenomeTrakr program data in peer-reviewed journals coauthored by the investigators and their US and international trainees. The major objective of the Administrative Core is to ensure all activities are completed according to the proposed approach in a coordinated, efficient manner. Accordingly, the specific aims are as follows. Aim 1: Provide leadership to complete the proposed aims in collaboration with national and international institutions. The investigators will provide strong leadership to ensure effective administration and fiscal management. Strong leadership will also help foster new and existing interactions between the members of this global network, which in turn will extend the GenomeTrakr database of WGS profiles and accompanying metadata by incorporating isolates and DNA received from national and international collaborators. The investigators have experience in working on extramural funded projects, meeting project deadlines, and providing progress reports to funding agencies. Aim 2: Provide a framework to educate and equip the future surveillance workforce with the knowledge and skills needed for WGS analysis. The Department of Population Health and Pathobiology at the NCSU College of Veterinary Medicine, where the investigating laboratories are located, is a World Health Organization (WHO) Collaborating Center for AMR and One Health. Under this status, the department performs a variety of activities to advance global foodborne pathogen and AMR surveillance, from capacity building to strengthen integrated surveillance of drug resistance in foodborne bacteria, to providing technical support such as global data sharing and knowledge dissemination among WHO member states. The investigators will leverage their extensive leadership experience in surveillance protocols, advanced molecular techniques and data analysis, and their status as a WHO Collaborating Center for AMR and One Health to build capacity in the US and globally through world-class training for students and professionals. Expected Outcomes: The investigators are committed to fulfilling the GenomeTrakr mission and expanding standardized surveillance systems across the globe. Through new and existing partnerships and building capacity in national and international locations, this work will help public health agencies track the emergence of new strains, curb the distribution of foodborne pathogens and reduce the burden of foodborne illnesses in the US and globally.

摘要：管理核心 自 2016 年以来，北卡罗来纳州立大学 (NCSU) 帮助在全国范围内扩展了 GenomeTrakr 项目 并在全球范围内针对全球食源性疾病的一些主要原因。以及表演的同时 先进的分子技术和数据分析，研究人员还提供了最先进的培训 为世界各地的学生和专业人士提供服务。迄今为止，NCSU GenomeTrakr 实验室已生成 3,328 从多个来源分离的细菌病原体的全基因组测序图谱。这包括 1,127 个 WGS 概况 过去三年从美国以外的 9 个国家分离出的细菌。他们还培训了23名学生 以及来自10个国家的专业人士，促成了GenomeTrakr计划的11份原创出版物 由研究人员及其美国和国际实习生共同撰写的同行评审期刊中的数据。 行政核心的主要目标是确保所有活动按照拟议的计划完成 采取协调一致、高效的方式。据此，具体目标如下。目标 1：提供 领导与国家和国际机构合作完成拟议目标。这 调查人员将提供强有力的领导，以确保有效的行政和财政管理。强的 领导力还将有助于促进这个全球网络成员之间新的和现有的互动， 反过来，将通过合并扩展 GenomeTrakr WGS 配置文件和随附元数据的数据库 从国内和国际合作者处获得的分离株和 DNA。调查人员有以下经验 从事外部资助的项目，按时完成项目，并提供资助进度报告 机构。目标 2：提供一个框架，为未来的监控人员提供相关知识的教育和装备 以及 WGS 分析所需的技能。北卡罗来纳州立大学人口健康与病理学系 调查实验室所在的兽医学院是世界卫生组织的一个机构 （世界卫生组织）抗菌素耐药性和同一个健康合作中心。在此状态下，该部门执行各种 推进全球食源性病原体和抗菌素耐药性监测的活动，从能力建设到加强 食源性细菌耐药性综合监测，提供全球等技术支持 世卫组织成员国之间的数据共享和知识传播。调查人员将利用他们的 在监测方案、先进分子技术和数据分析方面拥有丰富的领导经验， 及其作为世卫组织抗微生物药物耐药性和同一个健康合作中心的地位，以在美国和全球开展能力建设 通过为学生和专业人士提供世界一流的培训。预期结果：调查人员 致力于完成 GenomeTrakr 使命并在全球范围内扩展标准化监测系统 地球。通过新的和现有的合作伙伴关系以及在国家和国际地点的能力建设， 这项工作将帮助公共卫生机构追踪新菌株的出现，遏制食源性病毒的传播 病原体并减轻美国和全球食源性疾病的负担。