Administration Core

摘要：管理核心 自2016年以来，北卡罗来纳州州立大学（NCSU）帮助扩大了全国范围内的GenomeTrakr计划。 在全球范围内，针对全球食源性疾病的一些主要原因。以及执行 先进的分子技术和数据分析，研究人员还提供了最先进的培训 为全世界的学生和专业人士提供服务。迄今为止，NCSU GenomeTrakr实验室已经产生了3，328个 从多个来源分离的细菌病原体的WGS谱。这包括1，127个WGS配置文件 在过去三年中，来自美国以外9个国家的细菌分离株。他们还培训了23名学生 和来自10个国家的专业人士，这导致了GenomeTrakr计划的11个原始出版物 研究人员及其美国和国际学员共同撰写的同行评审期刊中的数据。 行政核心的主要目标是确保所有活动按照拟议的 以协调、高效的方式。因此，具体目标如下。目标1：提供 领导与国家和国际机构合作完成拟议目标。的 调查员将提供强有力的领导，以确保有效的行政和财政管理。强 领导力还将有助于促进这一全球网络成员之间新的和现有的互动， 反过来，将通过合并WGS配置文件和附带的元数据来扩展GenomeTrakr数据库 分离物和DNA来自国家和国际合作者。调查人员有经验， 从事校外资助的项目，满足项目的最后期限，并提供进度报告，以资助 社.目标2：提供一个框架，教育和装备未来的监测工作人员， 以及WGS分析所需的技能。NCSU的人口健康和病理学系 研究实验室所在的兽医学院是世界卫生组织 (WHO)AMR和One Health合作中心。在这种情况下，该部门执行各种 活动，以推进全球食源性病原体和AMR监测，从能力建设到加强 综合监测食源性细菌的耐药性，提供技术支持， 世卫组织成员国之间的数据共享和知识传播。调查人员将利用他们 在监测方案、先进分子技术和数据分析方面拥有丰富的领导经验， 及其作为世卫组织抗生素耐药性和同一健康合作中心的地位，以在美国和全球建立能力 为学生和专业人士提供世界一流的培训。预期结果：研究者 致力于完成GenomeTrakr的使命，并在全球范围内扩展标准化监测系统。 地球仪。通过新的和现有的伙伴关系以及国家和国际地点的能力建设， 这项工作将有助于公共卫生机构跟踪新菌株的出现，遏制食源性疾病的传播， 病原体和减少食源性疾病在美国和全球的负担。

Summary: Admin Core Since 2016, North Carolina State University (NCSU) has helped expand the GenomeTrakr program on a national and global scale to target some of the leading causes of foodborne illnesses worldwide. As well as performing advanced molecular techniques and data analysis, the investigators have also provided state-of-the-art training for students and professionals worldwide. To date, NCSU GenomeTrakr laboratories have generated 3,328 WGS profiles of bacterial pathogens isolated from multiple sources. This includes WGS profiles of 1,127 bacterial isolates from 9 countries outside the US over the last three years. They have also trained 23 students and professionals from 10 countries, which has led to 11 original publications of GenomeTrakr program data in peer-reviewed journals coauthored by the investigators and their US and international trainees. The major objective of the Administrative Core is to ensure all activities are completed according to the proposed approach in a coordinated, efficient manner. Accordingly, the specific aims are as follows. Aim 1: Provide leadership to complete the proposed aims in collaboration with national and international institutions. The investigators will provide strong leadership to ensure effective administration and fiscal management. Strong leadership will also help foster new and existing interactions between the members of this global network, which in turn will extend the GenomeTrakr database of WGS profiles and accompanying metadata by incorporating isolates and DNA received from national and international collaborators. The investigators have experience in working on extramural funded projects, meeting project deadlines, and providing progress reports to funding agencies. Aim 2: Provide a framework to educate and equip the future surveillance workforce with the knowledge and skills needed for WGS analysis. The Department of Population Health and Pathobiology at the NCSU College of Veterinary Medicine, where the investigating laboratories are located, is a World Health Organization (WHO) Collaborating Center for AMR and One Health. Under this status, the department performs a variety of activities to advance global foodborne pathogen and AMR surveillance, from capacity building to strengthen integrated surveillance of drug resistance in foodborne bacteria, to providing technical support such as global data sharing and knowledge dissemination among WHO member states. The investigators will leverage their extensive leadership experience in surveillance protocols, advanced molecular techniques and data analysis, and their status as a WHO Collaborating Center for AMR and One Health to build capacity in the US and globally through world-class training for students and professionals. Expected Outcomes: The investigators are committed to fulfilling the GenomeTrakr mission and expanding standardized surveillance systems across the globe. Through new and existing partnerships and building capacity in national and international locations, this work will help public health agencies track the emergence of new strains, curb the distribution of foodborne pathogens and reduce the burden of foodborne illnesses in the US and globally.