Eukaryotic Gene Regulation (EGR) Predoctoral Training Program

项目总结 宾夕法尼亚州立大学的真核基因调控(EGR)博士前培训计划将培养下一代 在实验、分子和计算科学领域的科学家应用于理解机制 真核基因调控。培训计划将建立在现有的研究生计划的基础上 生物化学、分子、细胞和发育生物学、生物信息学和基因组学。废气再循环的目标 计划与国家细胞、生化和分子科学(CMB)计划一致 全科医学研究所。该计划旨在培养跨学科学习和培养新的 与生物学问题以及细胞和分子科学有关的科学家，以促进科学和改进 健康。生物学和人类疾病的几乎所有方面都植根于基因调控。我们的知识和 理解、控制和纠正基因表达和错误表达的能力是基本的 知识细胞和基本的医学知识。美国癌症协会最近的一份报告发现 我们正在赢得抗癌战争的部分原因是我们对基因的基本机制的理解 控制力。然而，很明显，我们必须继续战斗。这场战斗将需要科学家在 实验和计算科学。拟议的EGR培训计划将培训一批不同的 学生科学家在生物物理、生物化学、分子生物学、遗传学、 计算生物学，以及解决基因调控基本问题的统计学。该计划将是 固定在真核基因调控中心(CEGR)内，该中心已被特许给这些 20多年来的原则。宾夕法尼亚州立大学的CEGR因生产出杰出的 科学。该培训计划将连接并进一步发展五个已建立的研究生课程：生物化学 和分子生物学(BMMB)、化学(CHEM)、化学工程(CHE)、分子细胞和 综合生物科学(MCIBS)和生物信息学与基因组学(MCIBS-BG)。美国国立卫生研究院和宾夕法尼亚州立大学 在州政府的支持下，EGR项目计划在五年内培养至少13名博士前学生。 每名学员将接受为期两年的培训(2年级和3年级)，同时接受基础培训 关于废气再循环的培训。学员将彻底了解科学过程、负责任的行为 科学，熟练掌握创新的研究方法，能够利用基因组学和统计工具 推进全基因组实验方法，在跨学科交流方面卓有成效，以及 在跨学科研究团队中的领导力。

PROJECT SUMMARY The Penn State ‘Eukaryotic Gene Regulation (EGR) Predoctoral Training Program’ will train a future generation of scientists in experimental, molecular and computational sciences applied towards understanding mechanisms of eukaryotic gene regulation. The training program will build upon established graduate programs in biochemistry, molecular, cellular and developmental biology, bioinformatics and genomics. The goals of the EGR program are consistent with the Cellular, Biochemical and Molecular Sciences (CMB) program at National Institute of General Medicine. The program aims to cultivate interdisciplinary study and the training of new scientists pertaining to biological problems and cellular and molecular sciences to advance science and improve health. Nearly all aspects of biology and human disease are rooted in gene regulation. Our knowledge and abilities to understand, control, and rectify gene expression and mis-expression is fundamental to the basic knowledge cells and to the basic knowledge of medicine. A recent report from the American Cancer Society finds that we are winning the war on cancer in part because of our understanding of fundamental mechanisms of gene control. However, it is also clear that we must keep up the fight. This fight will require scientists cross-trained in experimental and computational sciences. The proposed EGR training program will train a diverse cohort of student-scientists to have critical expertise in biophysics, biochemistry, molecular biology, genetics, computational biology, and statistics to address fundamental questions in gene regulation. The program will be anchored within the Center for Eukaryotic Gene Regulation (CEGR), which has been chartered to these principles for over 20 years. Penn State’s CEGR has a long-standing reputation for producing outstanding science. This training program will connect and further develop five established graduate programs: Biochemistry and Molecular Biology (BMMB), Chemistry (CHEM), Chemical Engineering (CHE), Molecular Cellular and Integrative Biosciences (MCIBS), and Bioinformatics and Genomics (MCIBS-BG). Combining NIH and Penn State support, the EGR program plans to train a minimum of 13 predoctoral students over a period of five years. Each trainee will be supported for the two years of their training (year 2 and 3) while receiving foundational training in EGR. Trainees will gain a thorough understanding of the scientific process, responsible conduct in science, fluency in innovative research methodologies, ability to utilize genomics and statistical tools in advancing genome-wide experimental approaches, excellence in cross-disciplinary communication, and leadership in cross-disciplinary research teams.