Administrative Core

内布拉斯加大学饮食分子预防肥胖疾病中心(NPOD) 内布拉斯加州支持对生物信号(主要是食源性信号)的识别研究，这些信号可以预防、治疗、 以及治疗肥胖症和肥胖相关疾病。NPOD，生物医学研究卓越中心(Cobre)， 是以加强代谢、肥胖和营养研究基础设施为指导的 并增强NPOD调查人员竞争外部研究资金的能力-同时 为抗击全国肥胖症流行做出了重大研究贡献。对NPOD的能力至关重要 有效和高效地运作是一个强有力的行政核心，它提供方案领导， 确保中心成功所需的行政支持和基础设施。重要的是， 行政核心将保持其领导层和外部和内部成员的连续性 在科布雷第二阶段期间的咨询委员会。在第一阶段期间，行政核心发挥了重要作用 几个关键指标证明了NPOD在NPOD成功中的作用。NPOD初级调查人员发表了154篇同行- 审查出版物并获得约3100万美元的研究资金，其中包括11项主要研究赠款 来自NIH(三个R01，一个R21，一个R35)，美国农业部(三个)，美国心脏 协会(两个)，以及比尔和梅林达·盖茨基金会。中心成员增加到51个多学科 16个单位的调查人员拥有超过9600万美元的外部研究资金。管理核心确保了额外的 为NPOD研究核心提供空间和设备，并将通过以下方式在中心第二阶段的成功中发挥关键作用 利用NIH的资金和机构承诺，为四个系的五个新教师职位(外加一个 UNL卓越计划聘用营养基因组学)，约120万美元用于启动一揽子计划，以及更多 100万美元的现金用于支持试点、种子和修订资助计划、导师激励和设备 购买。行政核心将利用这些承诺和第一阶段的成功1)增加 通过新聘人员、飞行员和种子进行多学科研究的中心调查人员的临界数量 赠款，并通过提供P01(或RM1)试点赠款资金，促进提交大规模提案； 2)协助初级调查员向独立调查员身份过渡，为以下人员提供酬金 外部和内部导师，支持具有里程碑的个人发展计划，形成性和 总结性评估，以及通过旅行支持和客座教授计划建立联系的机会；3) 通过协调实验中的服务来支持生物医学和肥胖研究核心的成功 设计、大数据处理、生物统计和生物信息学分析，并促进收购 第二阶段计划增加五个新设备的体制承诺的设备；和4)扩大 中心研究的范围包括临床和转化性研究，方法是招聘新员工并考虑 项目负责人职位的21名候选人中有9人专注于临床和转化性研究。

The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) at the University of Nebraska supports research on the identification of biological, mainly food-borne, signals that prevent, treat, and cure obesity and obesity-related diseases. NPOD, a Center of Biomedical Research Excellence (COBRE), is guided by the overarching goals to strengthen the metabolic, obesity, and nutrition research infrastructure in Nebraska and enhance the ability of NPOD investigators to compete for external research funding – all while making significant research contributions to combatting the national obesity epidemic. Critical to NPOD's ability to operate effectively and efficiently is a strong Administrative Core that provides the programmatic leadership, administrative support, and infrastructure necessary to ensure the center is successful. Importantly, the Administrative Core will maintain continuity in its leadership and the membership of its external and internal advisory committees during COBRE Phase 2. During Phase 1, the Administrative Core played an instrumental role in NPOD success as evidenced by several key metrics. NPOD junior investigators published 154 peer- reviewed publications and secured approximately $31M in research dollars, including 11 major research grants from NIH (three R01, one R21, one R35), the U.S. Department of Agriculture (three), the American Heart Association (two), and the Bill and Melinda Gates Foundation. Center membership grew to 51 multidisciplinary investigators in 16 units with over $96M in external research funding. The Administrative Core secured additional space and equipment for NPOD's Research Core and will play a key role in the center's Phase 2 success by leveraging NIH funding and institutional commitments for five new faculty positions in four departments (plus a UNL Program of Excellence hire in nutrigenomics), approximately $1.2M toward start-up packages, and over $1M in cash matches in support of pilot, seed, and revision grant programs, mentor incentives, and equipment purchases. The Administrative Core will leverage these commitments and Phase 1 successes to 1) increase the critical mass of center investigators conducting multidisciplinary research through new hires, pilot and seed grants, and facilitate the submission of large-scale proposals through providing P01 (or RM1) pilot grant funding; 2) facilitate the transition of junior investigators to independent investigator status by providing honoraria for external and internal mentors, support for individual development plans with milestones, formative and summative evaluations, and networking opportunities via travel support and a visiting professors program; 3) support the success of the Biomedical and Obesity Research Core by coordinating services in experimental design, large data processing, and biostatistics and bioinformatics analyses and facilitating the acquisition of equipment with institutional commitments for five new equipment additions planned in Phase 2; and 4) broaden the scope of center research to include clinical and translational research by recruiting a new hire and considering nine in a pipeline of 21 candidates for project leader slots who have a focus on clinical and translational research.