Administrative Core

行政核心

• 批准号: 10186764
• 负责人: JANOS ZEMPLENI
• 金额: $ 76.6万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10186764
• 关键词: Address; Advisory Committees; Agriculture; American Heart Association; Award; Basic Science; Bioinformatics; Biological; Biomedical Research; Biometry; Center for Translational Science Activities; Centers of Research Excellence; Clinical; Clinical Research; Collaborations; Data Analyses; Development; Development Plans; Disease; Ensure; Equipment; Europe; Evaluation; Event; Experimental Designs; Faculty; Fostering; Foundations; Funding; Goals; Grant; Health; Incentives; Individual; Infrastructure; Institution; Interdisciplinary Study; Lead; Leadership; Medical center; Mentors; Metabolic; National Institute of Diabetes and Digestive and Kidney Diseases; Nebraska; Nutritional Study; Obesity; Obesity Epidemic; Obesity associated disease; Peer Review; Phase; Play; Positioning Attribute; Publications; Publishing; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; S Phase; Secure; Seeds; Services; Signal Transduction; Strategic Planning; Supercomputing; Translational Research; Travel; United States National Institutes of Health; Universities; Vision; Visit; cohort; combat; community based participatory research; computerized data processing; data acquisition; dietary; equipment acquisition; foodborne; improved; member; multidisciplinary; nutrition; nutritional genomics; obesity prevention; prevent; professor; programs; recruit; square foot; statistics; success

The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) at the University of Nebraska supports research on the identification of biological, mainly food-borne, signals that prevent, treat, and cure obesity and obesity-related diseases. NPOD, a Center of Biomedical Research Excellence (COBRE), is guided by the overarching goals to strengthen the metabolic, obesity, and nutrition research infrastructure in Nebraska and enhance the ability of NPOD investigators to compete for external research funding – all while making significant research contributions to combatting the national obesity epidemic. Critical to NPOD's ability to operate effectively and efficiently is a strong Administrative Core that provides the programmatic leadership, administrative support, and infrastructure necessary to ensure the center is successful. Importantly, the Administrative Core will maintain continuity in its leadership and the membership of its external and internal advisory committees during COBRE Phase 2. During Phase 1, the Administrative Core played an instrumental role in NPOD success as evidenced by several key metrics. NPOD junior investigators published 154 peer- reviewed publications and secured approximately $31M in research dollars, including 11 major research grants from NIH (three R01, one R21, one R35), the U.S. Department of Agriculture (three), the American Heart Association (two), and the Bill and Melinda Gates Foundation. Center membership grew to 51 multidisciplinary investigators in 16 units with over $96M in external research funding. The Administrative Core secured additional space and equipment for NPOD's Research Core and will play a key role in the center's Phase 2 success by leveraging NIH funding and institutional commitments for five new faculty positions in four departments (plus a UNL Program of Excellence hire in nutrigenomics), approximately $1.2M toward start-up packages, and over $1M in cash matches in support of pilot, seed, and revision grant programs, mentor incentives, and equipment purchases. The Administrative Core will leverage these commitments and Phase 1 successes to 1) increase the critical mass of center investigators conducting multidisciplinary research through new hires, pilot and seed grants, and facilitate the submission of large-scale proposals through providing P01 (or RM1) pilot grant funding; 2) facilitate the transition of junior investigators to independent investigator status by providing honoraria for external and internal mentors, support for individual development plans with milestones, formative and summative evaluations, and networking opportunities via travel support and a visiting professors program; 3) support the success of the Biomedical and Obesity Research Core by coordinating services in experimental design, large data processing, and biostatistics and bioinformatics analyses and facilitating the acquisition of equipment with institutional commitments for five new equipment additions planned in Phase 2; and 4) broaden the scope of center research to include clinical and translational research by recruiting a new hire and considering nine in a pipeline of 21 candidates for project leader slots who have a focus on clinical and translational research.

内布拉斯加大学通过膳食分子预防肥胖病中心（NPOD） 内布拉斯加州的研究支持生物识别的研究，主要是食物传播的，信号，预防，治疗， 治疗肥胖症和与肥胖相关的疾病。NPOD是生物医学研究卓越中心（COBRE）， 是指导的总体目标，以加强代谢，肥胖和营养研究基础设施， 内布拉斯加州和提高NPOD调查人员竞争外部研究资金的能力-所有同时 为抗击全国肥胖流行病做出了重大的研究贡献。对NPOD的能力至关重要 有效和高效地运作是一个强大的行政核心，提供方案领导， 行政支持和基础设施，以确保中心的成功。重要的是 行政核心将保持其领导层及其外部和内部成员的连续性。 COBRE第二阶段的咨询委员会。在第一阶段，行政核心发挥了重要作用， 在NPOD成功中的作用，这一点通过几个关键指标得到了证明。NPOD初级研究人员发表了154篇同行- 审查出版物，并获得约3100万美元的研究经费，包括11项主要研究赠款 来自NIH（三个R 01，一个R21，一个R35），美国农业部（三个），美国心脏病协会（三个）， 协会（两个）和比尔和梅林达盖茨基金会。中心成员增加到51个多学科 16个单位的研究人员，拥有超过9600万美元的外部研究资金。行政核心获得了额外的 为NPOD的研究核心提供空间和设备，并将在该中心的第二阶段成功中发挥关键作用， 利用NIH的资金和机构承诺，在四个部门（加上一个 UNL营养基因组学卓越招聘计划），约120万美元用于启动包，以及 100万美元的现金匹配，用于支持试点、种子和修订补助金计划、导师激励和设备 采购.行政核心将利用这些承诺和第一阶段的成功，1）增加 通过新员工、试点和种子进行多学科研究的中心研究人员的临界质量 赠款，并通过提供P01（或RM 1）试点赠款资金促进大规模提案的提交; 2)为初级调查员向独立调查员过渡提供酬金， 外部和内部导师，支持个人发展计划与里程碑，形成和 总结性评估，并通过旅行支持和访问教授计划提供网络机会; 3） 支持生物医学和肥胖研究核心的成功，通过协调实验服务， 设计，大数据处理，生物统计学和生物信息学分析，并促进获取 第二阶段计划增加的五个新设备的机构承诺设备;以及4）扩大 通过招募新员工并考虑将临床和转化研究纳入中心研究范围 21名候选人中的9名候选人将专注于临床和转化研究。