Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

摘要- 内布拉斯加大学通过膳食分子预防肥胖病中心（NPOD） 内布拉斯加州的研究支持生物信号的识别，预防，治疗和治愈肥胖， 相关疾病。NPOD的重点是食源性信号。由内布拉斯加大学林肯分校牵头 (UNL)NPOD研究人员与内布拉斯加大学医学中心密切合作， 16个单位的终身制住宅，跨越基础和临床科学，包括营养学，化学工程， 生物化学，胃肠病学和公共卫生，使NPOD真正的多学科的奋进。NPOD 长期目标是加强内布拉斯加州的生物医学研究基础设施，同时与肥胖作斗争，这是一个主要的问题。 影响美国公民的健康问题。NPOD的生物医学卓越研究中心（COBRE）第一阶段 成功包括超过9600万美元的外部资金奖励，以支持研究和375个学术出版物， 中心的主题。10名初级研究人员通过两个队列接受了指导，五个队列中有四个 1名项目领导人从国家方案发展司支助中毕业，并成为独立调查员 在中心。第五名项目负责人在毕业前前往欧洲任职。第二组5人 项目负责人正处于辅导期的中期。在第一阶段雇用了四名新教师， 该中心奠定了必要的基础，以建立一个临界质量的研究人员：NPOD的成员有 从中心成立时的13名教员发展到目前的51名调查员。在第1阶段，NPOD 翻新UNL校园的空间，以创建一个研究核心，并在核心价值安装新设备 738，500美元，以满足中心成员不断变化的需求。管理核心提供对计划的监督 确保中心有效运作。NPOD在第一阶段的许多成功使其定位于 通过旨在最大限度地提高中心成功率的战略活动，利用第2阶段COBRE资金。具体地说， NPOD将：1）通过在研究中心增加五名初级研究员来增加研究人员的临界质量。 内布拉斯加大学，招募新的初级和高级调查员的中心使用试点和种子赠款 资金，并继续发展战略联盟与整个国家的互补方案， 内布拉斯加州; 2）为研究核心获得额外的设备，并正式确定实验设计 通过行政核心提供的服务; 3）加强中心的指导结构， 协作，多学科的环境;和4）实施招聘和招聘方法，以扩大 基础营养和肥胖研究与临床、转化和社区研究的整合。通过 在完成了第二阶段的工作之后，NPOD将按计划过渡到COBRE第三阶段，然后继续进行 NPOD的愿景是成为NIH指定的营养和肥胖研究中心。

SUMMARY – PARENT PROJECT The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) at the University of Nebraska supports research on the identification of biological signals that prevent, treat, and cure obesity and related diseases. The emphasis of NPOD is on food-borne signals. Led by the University of Nebraska-Lincoln (UNL) in close collaboration with the University of Nebraska Medical Center, NPOD investigators have their tenure homes in 16 units crossing basic and clinical sciences, including nutrition, chemical engineering, biochemistry, gastroenterology, and public health, making NPOD a truly multidisciplinary endeavor. NPOD's long-term goal is to enhance the biomedical research infrastructure in Nebraska while combating obesity, a major health problem impacting U.S. citizens. NPOD's Centers of Biomedical Research Excellence (COBRE) Phase 1 successes include over $96M in external funding awards to support research and 375 scholarly publications on the center's theme. Ten junior investigators have been mentored through two cohorts, with four of the five Cohort 1 project leaders graduating from NPOD support and establishing themselves as independent investigators within the center. The fifth project leader departed for a position in Europe prior to graduation. Cohort 2's five project leaders are in the middle of their mentoring period. The hire of four new faculty during Phase 1 enabled the center to lay the groundwork necessary to establish a critical mass of researchers: NPOD's membership has grown from 13 faculty at the center's inception to its current count of 51 investigators. During Phase 1, NPOD renovated space on the UNL campus to create a research core and installed new equipment in the core worth $738,500 to meet the evolving needs of center members. An Administrative Core provides oversight of program activities to ensure the center functions effectively. NPOD's many successes in Phase 1 have positioned it to leverage Phase 2 COBRE funding via strategic activities designed to maximize center success. Specifically, NPOD will 1) increase its critical mass of researchers by hiring an additional five junior investigators at the University of Nebraska, recruiting new junior and senior investigators to the center using pilot and seed grant funding, and continuing to develop strategic alliances with complementary programs across the state of Nebraska; 2) acquire additional equipment for the research core and formalize experimental design services offered through the administrative core; 3) enhance the center's mentoring structure and collaborative, multidisciplinary environment; and 4) implement hiring and recruitment approaches to expand integration of fundamental nutrition and obesity research with clinical, translational, and community research. By the completion of Phase 2, NPOD will be on-track for transitioning into COBRE Phase 3 and then pursuit of NPOD's vision to become an NIH-designated Nutrition and Obesity Research Center.