Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

内布拉斯加州通过膳食分子预防肥胖病中心

• 批准号: 10456031
• 负责人: JANOS ZEMPLENI
• 金额: $ 233.08万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456031
• 关键词: Address; Adult; American; Area; Award; Basic Science; Biochemistry; Bioinformatics; Biological; Biomedical Research; Center for Translational Science Activities; Centers of Research Excellence; Chemical Engineering; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Complement; Consultations; Data Analytics; Development; Dietitian; Disease; Ensure; Environment; Epidemic; Equipment; Europe; Evaluation; Experimental Designs; Faculty; Fee-for-Service Plans; Funding; Gases; Gastroenterology; Goals; Grant; Health; Health Food; Home; Human; Individual; Inflammation; Infrastructure; Intervention; Laboratories; Laboratory Animals; Malignant Neoplasms; Medical Care Costs; Medical center; Mentors; Metabolic Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Nebraska; Obesity; Obesity associated disease; Overweight; Peer Review; Phase; Play; Positioning Attribute; Process; Public Health; Publications; Quality of life; Records; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Support; Secure; Seeds; Series; Services; Signal Transduction; Specialist; Strategic Planning; Structure; Training; Translating; Translational Research; Travel; Treatment Cost; United States National Institutes of Health; Universities; Vision; Visit; Wages; cohort; combat; community based participatory research; community based research; cost; design; dietary; exosome; foodborne; improved; lipid metabolism; member; metabolic abnormality assessment; multidisciplinary; non-alcoholic fatty liver disease; nutrition; nutritional genomics; obesity prevention; prevent; professor; programs; recruit; square foot; statistics; success; symposium

PROJECT SUMMARY/ABSTRACT The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) supports research on the identification of biological signals that prevent, treat, and cure obesity and related diseases. The emphasis of NPOD is on food-borne signals. Led by the University of Nebraska-Lincoln (UNL) in close collaboration with the University of Nebraska Medical Center (UNMC), NPOD investigators have their tenure homes in 16 units crossing basic and clinical sciences, including nutrition, chemical engineering, biochemistry, gastroenterology, and public health, making NPOD a truly multidisciplinary endeavor. NPOD’s long-term goal is to enhance the biomedical research infrastructure in Nebraska while combating obesity, a major health problem impacting U.S. citizens. NPOD’s Centers of Biomedical Research Excellence (COBRE) Phase 1 successes include over $96M in external funding awards to support research and 375 scholarly publications on the center’s theme. Ten junior investigators have been mentored through two cohorts, with four of the five Cohort 1 project leaders graduating from NPOD support and establishing themselves as independent investigators within the center. The fifth project leader departed for a position in Europe prior to graduation. Cohort 2’s five project leaders are in the middle of their mentoring period. The hire of four new faculty during Phase 1 enabled the center to lay the groundwork to build a critical mass of researchers: NPOD’s membership has grown from 13 faculty at the center’s inception to its current count of 51 investigators. During Phase 1, NPOD renovated space and added equipment worth over $1M to create the Biomedical and Obesity Research Core comprised of an Obesity and Nutrition Laboratory (1,976 sq. ft.) and Animal Laboratory (606 sq. ft.). An Administrative Core provides oversight of program activities to ensure the center functions effectively. NPOD’s many successes in Phase 1 have positioned it to leverage Phase 2 COBRE funding and institutional commitments (e.g., five new hires, approximately $1.2M toward start-up packages, and over $1M in cash matches) via strategic activities designed to maximize center success. Specifically, during Phase 2 NPOD will 1) increase its critical mass of researchers with an additional five junior investigator hires at UNL and UNMC (and a nutrigenomics investigator hire through UNL’s Programs of Excellence), recruiting new junior and senior investigators to the center using pilot and seed grant funding, and continuing to develop strategic alliances with complementary programs in Nebraska; 2) acquire additional equipment for the Research Core and enhance rigor and reproducibility with statistics and bioinformatics consultations offered through the Administrative Core; 3) enhance the center’s mentoring structure and collaborative, multidisciplinary environment through the addition of external mentors and various center activities; and 4) expand integration of fundamental nutrition and obesity research with translational clinical and community-based research. By the completion of Phase 2, NPOD will be on-track for transitioning into COBRE Phase 3 and pursuit of NPOD’s vision to become an NIH-designated Nutrition and Obesity Research Center.

项目摘要/摘要 内布拉斯加州通过饮食分子预防肥胖疾病中心(NPOD)的支持 识别预防、治疗和治疗肥胖及相关疾病的生物信号的研究。这个 NPOD的重点是食物传播的信号。由内布拉斯加州大学林肯分校(UNL)领导 与内布拉斯加大学医学中心(UNMC)合作，NPOD调查人员拥有他们的终身教职 16个单元的家庭，涉及基础和临床科学，包括营养、化学工程、生物化学、 胃肠病和公共卫生，使NPOD成为一项真正的多学科努力。NPOD的长期目标是 加强内布拉斯加州的生物医学研究基础设施，同时与肥胖作斗争，肥胖是一个主要的健康问题 影响到美国公民。NPOD生物医学研究卓越中心(COBRE)第一阶段取得成功 包括超过9600万美元的外部资金奖励，以支持该中心的研究和375篇学术出版物 主题。十名初级调查员通过两个队列得到了指导，其中五个队列1项目中有四个 从NPOD支持中毕业并在内部确立自己独立调查人员的领导人 中间。第五位项目负责人在毕业前前往欧洲的一个职位。2‘S五位项目负责人 正处于他们的辅导期中期。在第一阶段雇用了四名新教员，使中心能够 建立一大批研究人员的基础工作：NPOD的成员从大学的13名教员增加到 该中心的成立使其目前有51名调查人员。在第一阶段，NPOD翻新了空间并增加了 价值超过100万美元的设备，以创建由肥胖和肥胖组成的生物医学和肥胖研究核心 营养实验室(1,976平方米)英国《金融时报》)和动物实验室(606平方米)FT.)。管理核心提供监督 计划活动，以确保中心有效运作。NPOD在第一阶段取得的许多成功 将其定位为利用第二阶段Cobre资金和机构承诺(例如，五名新员工， 大约120万美元用于启动一揽子计划，超过100万美元用于现金匹配)，通过设计的战略活动 最大限度地提高中锋的成功。具体地说，在第二阶段，NPOD将1)增加其研究人员的临界数量 在UNL和UNMC再招聘五名初级调查员(以及通过 UNL的卓越计划)，利用Pilot和SEED向中心招聘新的初级和高级调查人员 提供资金，并继续与内布拉斯加州的互补项目发展战略联盟；2) 为研究核心购置更多设备，并通过统计和 通过管理核心提供生物信息学咨询；3)加强中心的指导结构 通过增加外部导师和各种中心实现协作、多学科环境 活动；以及4)扩大基础营养和肥胖研究与翻译临床和 基于社区的研究。到第二阶段完成时，NPOD将走上过渡到Cobre的轨道 第三阶段和追求NPOD成为美国国立卫生研究院指定的营养和肥胖研究中心的愿景。